COMPARATIVE ANALYSIS OF APC TUMOR SUPPRESSOR PROTEIN EXPRESSION IN CANCEROUS AND NORMAL COLORECTAL SPECIMENS BY IMMUNOHISTOCHEMISTRY

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NIKBAKHT DASTJERDI MEHDI; MAHMOODI MEISAM

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Paper Information

Journal: Journal of Isfahan Medical School Year:2012 | Volume:29 | Issue:161 Page(s): 1529-1535

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Title

COMPARATIVE ANALYSIS OF APC TUMOR SUPPRESSOR PROTEIN EXPRESSION IN CANCEROUS AND NORMAL COLORECTAL SPECIMENS BY IMMUNOHISTOCHEMISTRY

Author(s)

NIKBAKHT DASTJERDI MEHDI | MAHMOODI MEISAM | Issue Writer Certificate

Keywords

APCQ2

COLORECTAL CANCERQ2

TUMOR SUPPRESSOR GENEQ2

IMMUNOHISTOCHEMISTRYQ2

Abstract

Background: APC is a tumor-suppressor protein. To evaluate the correlation between APC expression and pathogenesis of COLORECTAL CANCER, we investigated the expression of this protein in cancerous and normal colorectal tissues.Methods: APC expression was evaluated in 50 pairs of primary COLORECTAL CANCERs and corresponding normal colorectal tissues using immunohistochemical staining on paraffin-embedded sections.Findings: APC was expressed in all tissues. It was down-regulated in the COLORECTAL CANCER specimens compared with the matched normal tissues (P<0.001).Conclusion: APC expression may be a favorable biologic marker and a useful prognostic indicator in patients with COLORECTAL CANCER.

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APA: Copy

NIKBAKHT DASTJERDI, MEHDI, & MAHMOODI, MEISAM. (2012). COMPARATIVE ANALYSIS OF APC TUMOR SUPPRESSOR PROTEIN EXPRESSION IN CANCEROUS AND NORMAL COLORECTAL SPECIMENS BY IMMUNOHISTOCHEMISTRY. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 29(161), 1529-1535. SID. https://sid.ir/paper/49914/en

Vancouver: Copy

NIKBAKHT DASTJERDI MEHDI, MAHMOODI MEISAM. COMPARATIVE ANALYSIS OF APC TUMOR SUPPRESSOR PROTEIN EXPRESSION IN CANCEROUS AND NORMAL COLORECTAL SPECIMENS BY IMMUNOHISTOCHEMISTRY. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2012;29(161):1529-1535. Available from: https://sid.ir/paper/49914/en

IEEE: Copy

MEHDI NIKBAKHT DASTJERDI, and MEISAM MAHMOODI, “COMPARATIVE ANALYSIS OF APC TUMOR SUPPRESSOR PROTEIN EXPRESSION IN CANCEROUS AND NORMAL COLORECTAL SPECIMENS BY IMMUNOHISTOCHEMISTRY,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 29, no. 161, pp. 1529–1535, 2012, [Online]. Available: https://sid.ir/paper/49914/en

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