EFFECT OF ACUPUNCTURE TREATMENT ON LEVEL OF SERUM INTERFERON (IFN) -Γ IN BALB/C MODEL OF LEISHMANIA MAJOR INFECTION

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SHAKIBAPOUR MAHSHID; GHAFFARI HOSEINI SHERVIN; MAHMOODIEH MOHSEN; ROSTAMI FATEMEH; HEJAZI SEYED HOSSEIN

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2013 | Volume:31 | Issue:245 Page(s): 1077-1085

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Title

EFFECT OF ACUPUNCTURE TREATMENT ON LEVEL OF SERUM INTERFERON (IFN) -Γ IN BALB/C MODEL OF LEISHMANIA MAJOR INFECTION

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Keywords

LEISHMANIASISQ2

ACUPUNCTUREQ2

LEISHMANIA MAJORQ2

INTERFERON-GQ2

Abstract

Background: Cutaneous LEISHMANIASIS (CL) is an endemic parasitic disease in Iran. Current treatments for the disease are not satisfying, have many side effects and are expensive. The healing effect of T-helper 1 (Th1) immune response, especially interferon (IFN) -γ secretion in CL has been previously documented. It has been shown that ACUPUNCTURE, a traditional Chinese medicine, also might activate Th1 immune response. In this study, the effect of ACUPUNCTURE on serum level of IFN-γ in experimental CL of BALB/c mice was investigated.Methods: 60 BALB/c mice were experimentally infected with LEISHMANIA MAJOR and assigned randomly in to three groups: ACUPUNCTURE treatment group which were given the ACUPUNCTURE (thirty minutes daily, two days a week for 10 sessions) and intra-peritoneal diazepam, as a sedative agent; control group for diazepam which only received the diazepam; and a control group without any intervention. Serum level of IFN-γ was measured by means of ELISA at the beginning of the study and at sessions 5 and 10 of ACUPUNCTURE treatment in three groups.Findings: The mean serum level of IFN-γ was not significantly different between and within the groups at the beginning and at the sessions 5 and 10 of the therapy.Conclusion: This investigation showed that ACUPUNCTURE may not affect the serum level of IFN-γ in BALB/c model of CL. Moreover, diazepam does not interfere with the serum level of IFN-γ in such a study. Analysis of other immune factors and early measurement of IFN-γ in the course of treatment possibly may display the activated protective immune response against LEISHMANIASIS by ACUPUNCTURE.

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APA: Copy

SHAKIBAPOUR, MAHSHID, GHAFFARI HOSEINI, SHERVIN, MAHMOODIEH, MOHSEN, ROSTAMI, FATEMEH, & HEJAZI, SEYED HOSSEIN. (2013). EFFECT OF ACUPUNCTURE TREATMENT ON LEVEL OF SERUM INTERFERON (IFN) -Γ IN BALB/C MODEL OF LEISHMANIA MAJOR INFECTION . JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(245), 1077-1085. SID. https://sid.ir/paper/49777/en

Vancouver: Copy

SHAKIBAPOUR MAHSHID, GHAFFARI HOSEINI SHERVIN, MAHMOODIEH MOHSEN, ROSTAMI FATEMEH, HEJAZI SEYED HOSSEIN. EFFECT OF ACUPUNCTURE TREATMENT ON LEVEL OF SERUM INTERFERON (IFN) -Γ IN BALB/C MODEL OF LEISHMANIA MAJOR INFECTION . JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2013;31(245):1077-1085. Available from: https://sid.ir/paper/49777/en

IEEE: Copy

MAHSHID SHAKIBAPOUR, SHERVIN GHAFFARI HOSEINI, MOHSEN MAHMOODIEH, FATEMEH ROSTAMI, and SEYED HOSSEIN HEJAZI, “EFFECT OF ACUPUNCTURE TREATMENT ON LEVEL OF SERUM INTERFERON (IFN) -Γ IN BALB/C MODEL OF LEISHMANIA MAJOR INFECTION ,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 31, no. 245, pp. 1077–1085, 2013, [Online]. Available: https://sid.ir/paper/49777/en

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