METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS SURVIVED FROM ACUTE IYMPHOBLASTIC IEUKEMIA

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RAEISI N.; FATHIPOUR A.A.; HASHEMIPOUR MAHIN; ADIBI A.; FARAJZADEGAN Z.; MOAFI A.R.; AMINI A.GH.; TABIBI A.P.

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2009 | Volume:27 | Issue:96 Page(s): 298-305

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Title

METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS SURVIVED FROM ACUTE IYMPHOBLASTIC IEUKEMIA

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Keywords

ACUTE LYMPHOBLASTIC LEUKEMIAQ2

METABOLIC SYNDROMEQ3

OBESITYQ3

INSULIN RESISTANCEQ3

Abstract

Background: METABOLIC SYNDROME is one of the risk factors of cardiovascular diseases. This study was designed to determine the prevalence of METABOLIC SYNDROME in survivor of childhood ACUTE LYMPHOBLASTIC LEUKEMIA.Methods: In a descriptive cross-sectional study fifty-five ACUTE LYMPHOBLASTIC LEUKEMIA cases younger than 21 years-old (the mean age: 10.4 years) were selected randomly from those who referred to Al-Zahra and Seyedolshohada hospitals in Isfahan from Aug to Feb 2007. The METABOLIC SYNDROME was defined based on criteria analogous to those of the modified adult treatment III (ATP III). We measured body mass index, blood pressure, fasting blood sugar, serum lipoproteins and insulin levels in subjects with METABOLIC SYNDROME. Findings: 20% (11/55) of participants had METABOLIC SYNDROME. 91% (10/11) of affected subjects were male (P = 0.025) and the prevalence of METABOLIC SYNDROME (MS) was more in males compare to the females (30% versus 4.5%, P = 0.019). 25% (14/55) of cases were obese while 71% (10/14) of them had METABOLIC SYNDROME (P < 0.0001). High plasma insulin level and high blood pressure were detected in subjects with METABOLIC SYNDROME (P = 0.004 and P < 0.0001 respectively). No meaningful correlation was found between fasting blood sugar, high density lipoprotein, triglyceride and METABOLIC SYNDROME (P > 0.05). Conclusion: Survivors of childhood ACUTE LYMPHOBLASTIC LEUKEMIA are at risk for METABOLIC SYNDROME and its complications. The most prevalent risk factor in our study was OBESITY. Therefore close follow up in ACUTE LYMPHOBLASTIC LEUKEMIA treated patients is highly recommended.

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APA: Copy

RAEISI, N., FATHIPOUR, A.A., HASHEMIPOUR, MAHIN, ADIBI, A., FARAJZADEGAN, Z., MOAFI, A.R., AMINI, A.GH., & TABIBI, A.P.. (2009). METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS SURVIVED FROM ACUTE IYMPHOBLASTIC IEUKEMIA. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 27(96), 298-305. SID. https://sid.ir/paper/50084/en

Vancouver: Copy

RAEISI N., FATHIPOUR A.A., HASHEMIPOUR MAHIN, ADIBI A., FARAJZADEGAN Z., MOAFI A.R., AMINI A.GH., TABIBI A.P.. METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS SURVIVED FROM ACUTE IYMPHOBLASTIC IEUKEMIA. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2009;27(96):298-305. Available from: https://sid.ir/paper/50084/en

IEEE: Copy

N. RAEISI, A.A. FATHIPOUR, MAHIN HASHEMIPOUR, A. ADIBI, Z. FARAJZADEGAN, A.R. MOAFI, A.GH. AMINI, and A.P. TABIBI, “METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS SURVIVED FROM ACUTE IYMPHOBLASTIC IEUKEMIA,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 27, no. 96, pp. 298–305, 2009, [Online]. Available: https://sid.ir/paper/50084/en

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