EVALUATION OF THE FREQUENCY OF OSTEOPONTIN GENE POLYMORPHISM (RS28357094 T>G) AND ITS RECEPTOR GENE (ITGA4- RS1449263 A>G) IN MULTIPLE SCLEROSIS PATIENTS IN COMPARISON TO HEALTHY CONTROLS IN ISFAHAN, IRAN, POPULATION

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DADKHAH FAHIMEH; ALSAHEBFOSOUL FERESHTEH; ESKANDARI NAHID; SALEHI MANSOUR; ETEMADIFAR MASOUD; KAZEMI MOHAMMAD

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2016 | Volume:34 | Issue:380 Page(s): 422-429

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Title

EVALUATION OF THE FREQUENCY OF OSTEOPONTIN GENE POLYMORPHISM (RS28357094 T>G) AND ITS RECEPTOR GENE (ITGA4- RS1449263 A>G) IN MULTIPLE SCLEROSIS PATIENTS IN COMPARISON TO HEALTHY CONTROLS IN ISFAHAN, IRAN, POPULATION

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Keywords

MULTIPLE SCLEROSISQ1

POLYMORPHISMQ2

OPN GENEQ1

ITGA4 GENEQ1

Abstract

Background: MULTIPLE SCLEROSIS (MS) is a chronic autoimmune disease of the central nervous system (CNS). Various factors including genetic and environmental factors are involved in the prevalence of MS. The Osteopontin (OPN) and its receptor Integrins alpha-4/beta-1 (ITGA4) have important role in immune response, so their encoding gene could be considered as a candidate for susceptibility to MS diseases. In the present study, we evaluated the frequency of OPN (rs28357094T>G) and ITGA4 (rs1449263A>G) POLYMORPHISMs in MS patients compared with healthy controls in Isfahan, Iran population.Methods: Blood samples were collected from 100 patients with MULTIPLE SCLEROSIS and 100 healthy controls. After DNA extraction, OPN (rs28357094) and ITGA4 (rs1449263) POLYMORPHISMs were detected with high resolution melt real time polymerase chain reaction (HRM Real Time PCR) technique. The results were analyzed with the SPSS software.Findings: In this study, frequency of TT genotype (OPN-rs28357094) (P=0.020, OR=1.85) and AA genotype (ITGA4 - rs1449263) (P=0.012, OR=2.10) in Patients with MULTIPLE SCLEROSIS were higher than the control group significantly.Conclusion: The results of this study show that rs28357094 T>G on OPN GENE and ITGA4-rs1449263A > G POLYMORPHISMs were associated with susceptibility to MULTIPLE SCLEROSIS in Isfahan population.

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References

ROLE OF OSTEOPONTIN IN RHEUMATOID ARTHRITIS

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APA: Copy

DADKHAH, FAHIMEH, ALSAHEBFOSOUL, FERESHTEH, ESKANDARI, NAHID, SALEHI, MANSOUR, ETEMADIFAR, MASOUD, & KAZEMI, MOHAMMAD. (2016). EVALUATION OF THE FREQUENCY OF OSTEOPONTIN GENE POLYMORPHISM (RS28357094 T>G) AND ITS RECEPTOR GENE (ITGA4- RS1449263 A>G) IN MULTIPLE SCLEROSIS PATIENTS IN COMPARISON TO HEALTHY CONTROLS IN ISFAHAN, IRAN, POPULATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 34(380), 422-429. SID. https://sid.ir/paper/50269/en

Vancouver: Copy

DADKHAH FAHIMEH, ALSAHEBFOSOUL FERESHTEH, ESKANDARI NAHID, SALEHI MANSOUR, ETEMADIFAR MASOUD, KAZEMI MOHAMMAD. EVALUATION OF THE FREQUENCY OF OSTEOPONTIN GENE POLYMORPHISM (RS28357094 T>G) AND ITS RECEPTOR GENE (ITGA4- RS1449263 A>G) IN MULTIPLE SCLEROSIS PATIENTS IN COMPARISON TO HEALTHY CONTROLS IN ISFAHAN, IRAN, POPULATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2016;34(380):422-429. Available from: https://sid.ir/paper/50269/en

IEEE: Copy

FAHIMEH DADKHAH, FERESHTEH ALSAHEBFOSOUL, NAHID ESKANDARI, MANSOUR SALEHI, MASOUD ETEMADIFAR, and MOHAMMAD KAZEMI, “EVALUATION OF THE FREQUENCY OF OSTEOPONTIN GENE POLYMORPHISM (RS28357094 T>G) AND ITS RECEPTOR GENE (ITGA4- RS1449263 A>G) IN MULTIPLE SCLEROSIS PATIENTS IN COMPARISON TO HEALTHY CONTROLS IN ISFAHAN, IRAN, POPULATION,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 34, no. 380, pp. 422–429, 2016, [Online]. Available: https://sid.ir/paper/50269/en

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