JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)
Year:2016 | Volume:34 | Issue:380|Papers Count:7

Background: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS). Various factors including genetic and environmental factors are involved in the prevalence of MS. The Osteopontin (OPN) and its receptor Integrins alpha-4/beta-1 (ITGA4) have important role in immune response, so their encoding gene could be considered as a candidate for susceptibility to MS diseases. In the present study, we evaluated the frequency of OPN (rs28357094T>G) and ITGA4 (rs1449263A>G) polymorphisms in MS patients compared with healthy controls in Isfahan, Iran population.Methods: Blood samples were collected from 100 patients with multiple sclerosis and 100 healthy controls. After DNA extraction, OPN (rs28357094) and ITGA4 (rs1449263) polymorphisms were detected with high resolution melt real time polymerase chain reaction (HRM Real Time PCR) technique. The results were analyzed with the SPSS software.Findings: In this study, frequency of TT genotype (OPN-rs28357094) (P=0.020, OR=1.85) and AA genotype (ITGA4 - rs1449263) (P=0.012, OR=2.10) in Patients with multiple sclerosis were higher than the control group significantly.Conclusion: The results of this study show that rs28357094 T>G on OPN gene and ITGA4-rs1449263A > G polymorphisms were associated with susceptibility to multiple sclerosis in Isfahan population.

Background: Radiation therapy is used to treat and control advanced ovarian cancer with spread to abdominal peritoneum. In this study, a comparison between various plans of radiation therapy within the abdomen and pelvis was performed in order to achieve an effective treatment response.Methods: Contouring and planning of 20 patients with CT-scan of the abdomen and pelvis were done by TiGRT software. In order to compare the different types of treatment planning for the selected site, some common criteria in radiotherapy and H-index were used.Findings: Among these methods, it was found that the two methods of anterior-posterior and lateral with 18 MV energy and same weight have same level of protection of organs at risk. While the tangent method do not produce a reasonable result. Moreover in anterior-posterior method can be shown that the changing in energy and beam weight give a various results from PTV covering and dose uniformity aspects.Conclusion: Among the various treatment planning were seen that AP/PA with AP=6MV energy and weight 1, PA=18 MV and weight 1.5, for covering whole abdomen give a better results.

Background: This study carried out to assess co-authorship network of 1298 articles published in Journal of Isfahan Medical School (JIMS) during 2010-2014 using co-authorship network analysis.Methods: The study was done by scientometrics approach and using co-authorship network analysis that assessed macro and micro indicators of the network components of 1298 articles. Ravar Matrix, UCINET and VOSviewer software were used to draw and analyze the co-authorship network.Findings: Assessment of the authors' performance proved that Nilforoushzadeh (41), Akbari (37), Farajzadegn, and Haghjooye Javanmard (24) allocated the first ranking in the productivity index, respectively. Furthermore, analysis of co-authorship network demonstrated that in betweenness centrality index, Akbari (66271.648), Salehi (31756.54) and Rouzbahani (22056.004) had a good position in the network. According to the closeness centrality, Akbari (2.109), Salehi (2.102) and Ataei (2.096) possessed the shortest distance with other nodes.Conclusion: Scientific collaboration network of the medical domain in JIMS has the features of a small world network and is in conformity with the theory of 6° separation. Additionally, the study provide a good chance for the young investigators to identify the most active and creative researchers in scientific productivity to benefit from their knowledge and experiences through the scientific collaborations.

Background: Type 2 Diabetes is one of the most prevalent diseases of developing societies. Diabetic retinopathy which is considered as a specific complication in type 2 and 1 diabetes, is one of the most complications of diabetes. Blood sugar control and the duration of the illness and lipid profile [total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL)] are the most important factors in creating diabetic retinopathy. In this study the effect of lipid profile in creating retinopathy was evaluated as aside factors.Methods: The study was performed in the form of analytical-sectional. The society under study in this research includes 300 type 2 diabetic patients who have active cases in the center of diabetes of Hamadan city, Iran, during 2013-2014. The relationship between lipid profile and catching retinopathy were studied in them. The data was analyzed by SPSS software and c2 statistical test.Findings: Altogether 300 patients were studied. 167 people were catching diabetic retinopathy. From 167 people, 34 people suffer from diabetes less than 10 years and 133 people catching diabetes more than 10 years. The statistical analysis done on the similar people regarding to the duration of diabetes didn’t show any significant relationship between lipid profile and catching retinopathy in type 2 diabetic patients and its acuteness.Conclusion: Based on findings, lipid profile in type 2 diabetic patients didn’t show any significant relationship with catching retinopathy and its acuteness.

Despite all prevention methods, hepatitis B virus (HBV), which can cause acute and chronic hepatitis, cirrhosis and liver cancer, still has remained endemic in many areas and more than 350 million people are chronic carriers of this virus in the world. The incidence of hepatitis B infection has significantly decreased among the patients with end stage renal disease during the past few decades due to factors such as blood screening for HBsAg and anti-HBc, reducing the need for blood transfusion after the advent of erythropoietin, hepatitis B vaccination and the implementation of infection control measures in hemodialysis units. It seems that HBsAg test is sufficient for the diagnosis of HBV infection in most end stage renal disease (ESRD) patients. However since the biochemical tests often cannot be reliable to indicate the status of liver pathology, the liver biopsy is the best method to ascertain the activity of hepatitis and the degree of cirrhosis. It is often recommended when antiviral treatment is being considered and before kidney transplantation for assesses the activity of HBV-related liver disease. According to the side effects of interferon-alfa among dialysis patients, nucleoside analogs are better choices for the treatment of hepatitis B among these patients. Finally it should be noted that Entecavir is the recommended first-line oral medication for hepatitis B among these patients.