EFFECTS OF ESTROGEN THERAPY ON COGNITIVE PERFORMANCE DEFICIT INDUCED BYNUCLEUS BASALIS MAGNOCELLULARIS LESION: ANIMAL MODEL OF ALZHEIMER’S DISEASE

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DABIR NEDA; MOAZEDI AHMADALI; HAGHPARAST ABBAS; Khajepour Lotfollah; AKHOOND MOHAMMADREZA

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Journal: Journal of Isfahan Medical School Year:2016 | Volume:34 | Issue:370 Page(s): 64-73

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Title

EFFECTS OF ESTROGEN THERAPY ON COGNITIVE PERFORMANCE DEFICIT INDUCED BYNUCLEUS BASALIS MAGNOCELLULARIS LESION: ANIMAL MODEL OF ALZHEIMER’S DISEASE

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Keywords

ALZHEIMER’S DISEASEQ2

BASAL FOREBRAINQ1

COGNITIVE PERFORMANCEQ2

NUCLEUS BASALIS MAGNOCELLULARISQ1

ESTROGEN THERAPYQ2

Abstract

Background: COGNITIVE PERFORMANCE appears to diminish with age and passing of time, probably due to the BASAL FOREBRAIN cholinergic dysfunction. Given the physiological significance of the acute effect of estrogen, this study was conducted aiming to investigate the effect of 17b-estradiol treatment on COGNITIVE PERFORMANCE in NUCLEUS BASALIS MAGNOCELLULARIS (NBM) induced lesions.Methods: In this experimental study, 40 adult male Wistar rats were divided into five different groups (8 rat in each group): Control (intact), NBM lesion group, which received electrically-induced lesion (0.5 mA, 3s) in NBM, Sham group (the electrode was impaled into the NBM with no lesion), Estrogen group (lesion+45mg/kg 17b-estradiol) and Vehicle group (NBM lesion+200ml sesame oil). Acquisition and retention testing was done using an eight-radialarm maze, in which, the patterns of arm entries in each group was recorded for calculating correct choices, working memory errors, reference memory errors and latency.Findings: Bilateral NBM lesion showed the reduction of spatial memory acquisition in the form of increased working and reference memory errors (P<0.001). It further reduced these functions in retention testing (P<0.001) compared to the control group. Post-lesion treatment with 45 mg/kg estrogen improved the parameters of spatial memory errors in the acquisition and retention tasks comparing to the Sham group (P>0.05).Conclusion: Electrical NBM lesion can reduce spatial memory function. ESTROGEN THERAPY after brain injury improved cognitive disorder.

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APA: Copy

DABIR, NEDA, MOAZEDI, AHMADALI, HAGHPARAST, ABBAS, Khajepour, Lotfollah, & AKHOOND, MOHAMMADREZA. (2016). EFFECTS OF ESTROGEN THERAPY ON COGNITIVE PERFORMANCE DEFICIT INDUCED BYNUCLEUS BASALIS MAGNOCELLULARIS LESION: ANIMAL MODEL OF ALZHEIMER’S DISEASE. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 34(370), 64-73. SID. https://sid.ir/paper/50392/en

Vancouver: Copy

DABIR NEDA, MOAZEDI AHMADALI, HAGHPARAST ABBAS, Khajepour Lotfollah, AKHOOND MOHAMMADREZA. EFFECTS OF ESTROGEN THERAPY ON COGNITIVE PERFORMANCE DEFICIT INDUCED BYNUCLEUS BASALIS MAGNOCELLULARIS LESION: ANIMAL MODEL OF ALZHEIMER’S DISEASE. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2016;34(370):64-73. Available from: https://sid.ir/paper/50392/en

IEEE: Copy

NEDA DABIR, AHMADALI MOAZEDI, ABBAS HAGHPARAST, Lotfollah Khajepour, and MOHAMMADREZA AKHOOND, “EFFECTS OF ESTROGEN THERAPY ON COGNITIVE PERFORMANCE DEFICIT INDUCED BYNUCLEUS BASALIS MAGNOCELLULARIS LESION: ANIMAL MODEL OF ALZHEIMER’S DISEASE,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 34, no. 370, pp. 64–73, 2016, [Online]. Available: https://sid.ir/paper/50392/en

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