Journal of Isfahan Medical School
Year:2016 | Volume:34 | Issue:385|Papers Count:6

Background: This study compared the relationship between vitamin D deficiency and polycystic ovary syndrome (PCOS) in women with this syndrome in the city of Isfahan, Iran.Methods: The subject of this study consisted of 44 women with age range of 20-40 years old who were suffering from PCOS and referred to a fertility clinic of Beheshti Hospital, Isfahan, Iran. The control group were 44 healthy women who were 20 to 40 years old and they were selected randomly. Their height and weight measured by meter and scales that were attached to the wall and body mass index was calculated. They completed a questionnaire as well as any of the blood samples were taken for testing vitamin D. the analysis of independent t test and Mann-Whitney tests was used to compare the means and the Pearson correlation test has been applied to determine the correlation between two variables.Findings: In the studied group, there was no significant difference between age and height. Features such as age (P=0.29), height (P=0.71) Job (P=0.29) level of education (P=0.49) in the two groups were not significantly different, but, vitamin D levels in patients with PCOS were significantly different than the control group (P=0.006).Conclusion: The mean levels of vitamin D in patients with PCOS were lower than the control group, while the short fall was more in patients with higher body mass index (BMI).

Background: Laryngoscopy is an invasive technique which is associated with severe cardiovascular complications. This study compared the effects of two doses of tramadol hydrochloride (2mg/kg, 1mg/kg) on heart rate and blood pressure with control group after laryngoscopy and intubation in elective surgical patients.Methods: In this clinical trial performed in 2015, 180 candidates in Kashani care center, Isfahan, Iran, were randomly divided to control (no drugs were used), tramadol 1mg/kg and tramadol 2mg/kg groups. Heart rate, systolic blood pressure, diastolic blood pressure and mean arterial blood pressure were recorded immediately before, after, and 1, 3 and 5, 10 min after laryngoscopy. Data were analyzed using SPSS and ANOVA and Tukey post hoc tests.Findings: There were significant differences in systolic, diastolic and mean arterial pressure between control group and two doses of tramadol (P<0.05). Also in heart rate the differences were significant. The incidence of hypertension, tachycardia, hypotension and bradycardia were less in two doses of tramadol.Conclusion: Prescribing 2 mg/kg of tramadol causes more stable blood pressure and heart rate compared with control group.

Background: Apron used in diagnostic radiology to protect worker and patients who are exposed to unnecessary ionizing radiation, is based on lead. Although, this protection can prevent the passage of X-rays used in diagnostic radiology, but a lot of research is found that lead is a toxic metal. Therefore, a lead-free shield should be built which can be protect workers and patients from unnecessary ionizing radiation.Methods: In this method, the absorption edge of different metals in the range of the energy spectrum of diagnostic radiology was investigated. Then, with the effect of overlapping edges, different combinations of metals as input Monte Carlo simulation was considered. Information obtained from the Monte Carlo simulation defines how the composition and percentage metals can have maximum impact on reducing the transmission of X-rays from the shield.Findings: The results showed that for building lead-free shields, using 20% tin, 15% of tungsten and 45% of 20% bismuth-based polymer emulsion Poly vinyl Chloride (EPVC) combination is the best options which can reduce X-rays in the range of diagnostic radiology.Conclusion: Characterized by the use of absorption edge overlap effect in different metals we can build a lead-free shield that decreases the intensity of X-rays in the range of diagnostic radiology much better than lead shield.

Background: Contrast media-induced acute renal damage could lead to renal failure; so, recently much attention has been made on the efficacy of medicinal plants in prevention and treatment of various diseases, especially in kidney and liver complications.Methods: Forty rats were randomly divided into four groups of 10 consisting of control, contrast media, contrast media plus green tea and green tea pretreatment and contrast media group, respectively. After collecting blood samples from lateral tail vein blood urea nitrogen (BUN) and serum creatinine were measured for assessing tubular nephrotoxicity.Findings: In the second group creatinine level was significantly higher than other groups (P<0.05).Conclusion: Green tea can provide an applicable intervention approach in individuals with a risk for contrast induced acute kidney injury. So, further preclinical investigations are necessary to confirm the efficiency of this herb against various injurious substances to the renal tubular cells.

Background: Colorectal cancer (CRC) is one of the most common cancers in the world. High activity of CyclinD1 gene has been seen in the progress of this cancer. A common polymorphism (G870A) in exon 4 of CyclinD1 produces a variant transcript with longer half-life and may cause uncontrollable cellular growth thus contributing to cancer development. This study was performed to evaluate the frequency of CCND1 G870A polymorphism between CRC cases and controls.Methods: DNA samples from peripheral blood leukocytes of 50 patients with sporadic colorectal cancer and 50 healthy subjects were extracted. CCND1 G870A polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in healthy subjects and patients. Statistical analysis was performed by chi-squared test via SPSS software.Findings: Relationship between CCND1 G870A polymorphism in allele frequencies between cases and controls were not observed (P=0.204). While the frequency of AA genotype was significantly higher in patients (P=0.040, 95% CI=1.13-5.54, OR=2.25).Conclusion: According to the significant association observed between certain genotypes of this locus (AA) with colorectal cancer, it can be used in the future as a good prognostic marker in CRC screening programs.