EFFECT OF PIOGLITAZONE ON PROTEINURIA IN NON-DIABETIC RENAL PATIENTS: A SELF-CONTROL CLINICAL TRIAL

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SHAHIDI SHAHRZAD; PAKZAD BAHRAM; MORTAZAVI MOJGAN; SEIRAFIAN SHIVA; AKBARI MOJTABA; ATARPOUR ABDOLAMIR; SHAYGAN NEZHAD ALIREZA

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Journal: Journal of Isfahan Medical School Year:2010 | Volume:28 | Issue:112 Page(s): 632-639

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Title

EFFECT OF PIOGLITAZONE ON PROTEINURIA IN NON-DIABETIC RENAL PATIENTS: A SELF-CONTROL CLINICAL TRIAL

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Keywords

PROTEINURIAQ3

PIOGLITAZONEQ2

NON-DIABETIC RENAL DISEASEQ3

HYPOGLYCEMIC AGENTQ3

Abstract

Background: PROTEINURIA has independent deleterious effects on the progression of chronic renal disease.The aim of this study was to determine effect of PIOGLITAZONE on PROTEINURIA in patients with NON-DIABETIC RENAL DISEASE.Methods: This was a self-controlled clinical trial study conducted in Al-Zahara Hospital and few private clinics of nephrology in Isfahan. Forty four non- diabetic patients aged 18 and over, who had renal disease and stable PROTEINURIA over 0.5 g in 24h and body mass index (BMI) lower than 30 kg/m2 , were enrolled in the study. Patients were treated by 15 mg of PIOGLITAZONE for 4 months. The primary end point was urine protein excretion, measured prior to the study, at the end of 2 and 4 months during treatment as well as 2 months after cessation of PIOGLITAZONE. Secondary end points included systolic blood pressure, creatinine, ALT, AST, FBS, BUN and GFR levels.Findings: Mean urine protein excretion was 1088.6±775.6 mg124h before treatment; therefore mean urine protein excretion at the end of 4th month was 433.9±406.2 mg/24 h (P<0.001, CI 95%: 0.49-0.82).There was no significant trend for systolic blood pressure, creatinine, ALT, AST, FBS, BUN and GFR levels to increase or decrease during the follow-up period (P>0.01).Conclusion: Consietering complication s of PROTEINURIA followed by gradual kidney malfunction based on findings of present study, PIOGLITAZONE could significantly decrease PROTEINURIA in patients with non-diabetic kidney diseases.

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APA: Copy

SHAHIDI, SHAHRZAD, PAKZAD, BAHRAM, MORTAZAVI, MOJGAN, SEIRAFIAN, SHIVA, AKBARI, MOJTABA, ATARPOUR, ABDOLAMIR, & SHAYGAN NEZHAD, ALIREZA. (2010). EFFECT OF PIOGLITAZONE ON PROTEINURIA IN NON-DIABETIC RENAL PATIENTS: A SELF-CONTROL CLINICAL TRIAL. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 28(112), 632-639. SID. https://sid.ir/paper/50860/en

Vancouver: Copy

SHAHIDI SHAHRZAD, PAKZAD BAHRAM, MORTAZAVI MOJGAN, SEIRAFIAN SHIVA, AKBARI MOJTABA, ATARPOUR ABDOLAMIR, SHAYGAN NEZHAD ALIREZA. EFFECT OF PIOGLITAZONE ON PROTEINURIA IN NON-DIABETIC RENAL PATIENTS: A SELF-CONTROL CLINICAL TRIAL. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2010;28(112):632-639. Available from: https://sid.ir/paper/50860/en

IEEE: Copy

SHAHRZAD SHAHIDI, BAHRAM PAKZAD, MOJGAN MORTAZAVI, SHIVA SEIRAFIAN, MOJTABA AKBARI, ABDOLAMIR ATARPOUR, and ALIREZA SHAYGAN NEZHAD, “EFFECT OF PIOGLITAZONE ON PROTEINURIA IN NON-DIABETIC RENAL PATIENTS: A SELF-CONTROL CLINICAL TRIAL,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 28, no. 112, pp. 632–639, 2010, [Online]. Available: https://sid.ir/paper/50860/en

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