PREVALENCE OF OXA-2 AND OXA-10 TYPE ESBL AMONG ACINETOBACTER STRAINS ISOLATED FROM PATIENTS OF ZAHEDAN (SOUTH EASTERN IRAN)

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BOKAIAN MOHAMMAD; SHAHRAKI SHAHRAM; RAEISI JAN MOHAMMAD; MOHAMMADZADEH ROSTAMI FARZANEH

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Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:59 | Issue:1 Page(s): 26-34

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Title

PREVALENCE OF OXA-2 AND OXA-10 TYPE ESBL AMONG ACINETOBACTER STRAINS ISOLATED FROM PATIENTS OF ZAHEDAN (SOUTH EASTERN IRAN)

Author(s)

BOKAIAN MOHAMMAD | SHAHRAKI SHAHRAM | RAEISI JAN MOHAMMAD | MOHAMMADZADEH ROSTAMI FARZANEH | Issue Writer Certificate

Keywords

ACINETOBACTERQ2

ANTIBIOTIC RESISTANCEQ2

EXTENDED-SPECTRUM BETA-LACTAMASEQ2

BLA-OXA-2Q2

BLA-OXA-10Q1

ZAHEDANQ3

Abstract

Introduction: The most important factor in resistance to beta-lactam antibiotics in ACINETOBACTER family is EXTENDED-SPECTRUM BETA-LACTAMASEs (ESBLs) and OXA is one of the most common ESBL enzymes. The aim of this study was to determine the frequency of BLA-OXA-2 and BLA-OXA-10 resistance genes among ACINETOBACTER strains isolated from patients referred to teaching hospitals of ZAHEDAN city, Iran.Methods: This cross-sectional descriptive study was carried out on 100 ACINETOBACTER isolated from patients referred to teaching hospitals of ZAHEDAN, Iran in 2013-2014. The isolates were identified using standard biochemical and microbiological tests. ESBL production was determined in isolates by Combined Disc test. The presence of BLA-OXA-10 and BLA-OXA-2 in clinical isolates were investigated by PCR technique.Results: The results of antimicrobial sensitivity tests revealed that the highest resistance was against ampicillin (100%), oxacillin (100%), cefotaxime and cefexime (99%), whereas the highest susceptibility was observed for colistin (93%). PCR results showed that among the 24 isolates of ESBL positive, OXA-2 gene in 5 cases (20.8%) and OXA-10 in 4 cases (16.66%) were positive.Conclusion: The results of this study showed the presence of OXA-2 and OXA-10 type ESBLs among drug resistant ACINETOBACTER strains that reminded the necessity of preventive measures for inhibiting dissemination of these resistant isolates.

Cites

Prevalence of IMP and SPM Genes in Clinical Isolates of Carbapenem Resistant Acinetobacter baumannii in Educational Hospitals of Sari, Iran

References

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APA: Copy

BOKAIAN, MOHAMMAD, SHAHRAKI, SHAHRAM, RAEISI, JAN MOHAMMAD, & MOHAMMADZADEH ROSTAMI, FARZANEH. (2016). PREVALENCE OF OXA-2 AND OXA-10 TYPE ESBL AMONG ACINETOBACTER STRAINS ISOLATED FROM PATIENTS OF ZAHEDAN (SOUTH EASTERN IRAN). MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 59(1), 26-34. SID. https://sid.ir/paper/51537/en

Vancouver: Copy

BOKAIAN MOHAMMAD, SHAHRAKI SHAHRAM, RAEISI JAN MOHAMMAD, MOHAMMADZADEH ROSTAMI FARZANEH. PREVALENCE OF OXA-2 AND OXA-10 TYPE ESBL AMONG ACINETOBACTER STRAINS ISOLATED FROM PATIENTS OF ZAHEDAN (SOUTH EASTERN IRAN). MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;59(1):26-34. Available from: https://sid.ir/paper/51537/en

IEEE: Copy

MOHAMMAD BOKAIAN, SHAHRAM SHAHRAKI, JAN MOHAMMAD RAEISI, and FARZANEH MOHAMMADZADEH ROSTAMI, “PREVALENCE OF OXA-2 AND OXA-10 TYPE ESBL AMONG ACINETOBACTER STRAINS ISOLATED FROM PATIENTS OF ZAHEDAN (SOUTH EASTERN IRAN),” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 59, no. 1, pp. 26–34, 2016, [Online]. Available: https://sid.ir/paper/51537/en

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