A COMPARATIVE IMMUNOHISTO CHEMICAL DIAGNOSIS OF HODGKIN’S LYMPHOMA WITH CONVENTIONAL METHOD

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MIRSADRAEE S.; FARZADNIA M.; HEIDARY F.; RAHIMI MAHDI; JABBARI NOGHABI H.; KAKHI S.

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Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2011 | Volume:53 | Issue:4 Page(s): 214-221

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Title

A COMPARATIVE IMMUNOHISTO CHEMICAL DIAGNOSIS OF HODGKIN’S LYMPHOMA WITH CONVENTIONAL METHOD

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Keywords

HODGKIN’S LYMPHOMAQ3

IMMUNOHISTOCHEMISTRYQ3

LYMPHOMAQ3

Abstract

Introduction: LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA is a malignant neoplasm of B lymphocytes and less common T lymphocytes that morphologically can be mistaken with several benign and malignant diseases. These diseases have different course, treatments and prognosis from LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA. Immunohistochemical staining is very useful that will aid in separating LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA from a series of benign and malignant lookalikes.Materials and Methods: We Randomly selected 53 cases with primary diagnosis of LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA in pathology laboratory of Imam Reza Hospital from 1374-1384. To confirm or rule out of the primary diagnosis, microscopic evaluation and Immunohistochemical staining were done.Results: Overall in 47 cases (88.7%), LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA was confirmed and 6 cases (11.3%) were non hodgkin LYMPHOMA.A total 5 cases were T cell Rich large B cell LYMPHOMA and 1 case was anaplasic large cell LYMPHOMA probably. In LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA cases, the mean age was 40 years. Except for nodular sclerosis other types were more frequent in males. (M/F = 2.5).The commonest type was mixed cellularity (39 cases) (54.7%).Conclusion: Misdiagnosis of LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA without Immunohistochemical staining was 11.3%. Because of significant difference between treatment and prognosis of LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA and other morphologically similar diseases, immunohistochemical staining particulary in lymphocytic depletion and nodular lymphocytic predominant LYMPHOMA/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HODGKIN’S LYMPHOMA, is necessary and recommended.

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APA: Copy

MIRSADRAEE, S., FARZADNIA, M., HEIDARY, F., RAHIMI, MAHDI, JABBARI NOGHABI, H., & KAKHI, S.. (2011). A COMPARATIVE IMMUNOHISTO CHEMICAL DIAGNOSIS OF HODGKIN’S LYMPHOMA WITH CONVENTIONAL METHOD. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 53(4), 214-221. SID. https://sid.ir/paper/52184/en

Vancouver: Copy

MIRSADRAEE S., FARZADNIA M., HEIDARY F., RAHIMI MAHDI, JABBARI NOGHABI H., KAKHI S.. A COMPARATIVE IMMUNOHISTO CHEMICAL DIAGNOSIS OF HODGKIN’S LYMPHOMA WITH CONVENTIONAL METHOD. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;53(4):214-221. Available from: https://sid.ir/paper/52184/en

IEEE: Copy

S. MIRSADRAEE, M. FARZADNIA, F. HEIDARY, MAHDI RAHIMI, H. JABBARI NOGHABI, and S. KAKHI, “A COMPARATIVE IMMUNOHISTO CHEMICAL DIAGNOSIS OF HODGKIN’S LYMPHOMA WITH CONVENTIONAL METHOD,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 53, no. 4, pp. 214–221, 2011, [Online]. Available: https://sid.ir/paper/52184/en

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