ASSOCIATION BETWEEN RS3745453 GENE POLYMORPHISM ANDTHE RISK OF MULTIPLE SCLEROSIS

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GOLSHANI ZEYNAB; HOJATI ZOHREH; SHARIFZADEH ALI; SHAYGANNEJAD VAHID; JAFARINIA MOJTABA

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Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:60 | Issue:5 Page(s): 681-688

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Title

ASSOCIATION BETWEEN RS3745453 GENE POLYMORPHISM ANDTHE RISK OF MULTIPLE SCLEROSIS

Author(s)

Keywords

POLYMORPHISMQ2

MICRO RNAQ1

MULTIPLE SCLEROSISQ2

Abstract

Introduction: MULTIPLE SCLEROSIS (MS) is a major autoimmune disease of the central nervous system. Today it is specified that changes in the sequence of single nucleotides or SNPs are associated with disease or resistance to disease. In recent studies, the association of micro-RNA POLYMORPHISM has been reported with diseases such as cancer and autoimmune diseases. MICRO RNA is a group of non-coding RNA that affects a variety of biological processes such as growth, cell division, and immunity. Materials&Methods: blood samples were collected from 71 MS patients and 71 healthy subjects, and DNA was extracted. Genotyping analysis was performed using TARMS PCR technique. The relationship between rs3745453 POLYMORPHISM and MS was evaluated by statistical tests. Results: TT, TC and CC genotypic frequencies are 34, 24 and 13 in patients and 39, 11 and 21% in control group respectively. In both groups, the TT genotype was dominant and heterozygote frequencies were higher in patients than control group. Odd ratio (OR) in TC genotype was 2. 7. In other words, heterozygote individuals have a 2. 7 times higher chance of MS than othersConclusion: This study was the first report of the relationship between mir23a POLYMORPHISM and MS disease. According to the results, we can say that mir 23a rs3745453 POLYMORPHISM is associated with MULTIPLE SCLEROSIS (P = 0. 029). It is suggested that further studies should be done with more samples.

Cites

The function of epigenetic processes in multiple sclerosis: review article

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APA: Copy

GOLSHANI, ZEYNAB, HOJATI, ZOHREH, SHARIFZADEH, ALI, SHAYGANNEJAD, VAHID, & JAFARINIA, MOJTABA. (2018). ASSOCIATION BETWEEN RS3745453 GENE POLYMORPHISM ANDTHE RISK OF MULTIPLE SCLEROSIS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 60(5 ), 681-688. SID. https://sid.ir/paper/52342/en

Vancouver: Copy

GOLSHANI ZEYNAB, HOJATI ZOHREH, SHARIFZADEH ALI, SHAYGANNEJAD VAHID, JAFARINIA MOJTABA. ASSOCIATION BETWEEN RS3745453 GENE POLYMORPHISM ANDTHE RISK OF MULTIPLE SCLEROSIS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;60(5 ):681-688. Available from: https://sid.ir/paper/52342/en

IEEE: Copy

ZEYNAB GOLSHANI, ZOHREH HOJATI, ALI SHARIFZADEH, VAHID SHAYGANNEJAD, and MOJTABA JAFARINIA, “ASSOCIATION BETWEEN RS3745453 GENE POLYMORPHISM ANDTHE RISK OF MULTIPLE SCLEROSIS,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 60, no. 5 , pp. 681–688, 2018, [Online]. Available: https://sid.ir/paper/52342/en

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