AN ASSOCIATION STUDY OF RS2829803 POLYMORPHISM IN MIRNA-155 WITH MULTIPLE SCLEROSIS IN PATIENTS REFERRED TO FARSHCHIAN HOSPITAL OF HAMADAN CITY, (IRAN)

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ABOLFATHIRAD SANAZ; SARI SOYAR; MIRFAKHRAIE REZA

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2018 | Volume:12 | Issue:2 Page(s): 28-34

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Title

AN ASSOCIATION STUDY OF RS2829803 POLYMORPHISM IN MIRNA-155 WITH MULTIPLE SCLEROSIS IN PATIENTS REFERRED TO FARSHCHIAN HOSPITAL OF HAMADAN CITY, (IRAN)

Author(s)

ABOLFATHIRAD SANAZ | SARI SOYAR | MIRFAKHRAIE REZA | Issue Writer Certificate

Keywords

MULTIPLE SCLEROSISQ1

MICRORNASQ2

POLYMORPHISMQ1

GENETICQ1

Abstract

Background and Objectives: MULTIPLE SCLEROSIS is a chronic autoimmune disease with inflammation of the myelin sheath of the central nervous system. A series of factors, such as environmental factors and POLYMORPHISMs have been known to be associated with it. In this study, the correlation between POLYMORPHISM of rs2829803 in miR-155 and MULTIPLE SCLEROSIS, was investigated in the patients referred to Farshchian Hospital of Hamadan City.Methods: In this case-control study, 130 patients (29% male, 71% female) with MULTIPLE SCLEROSIS (age range, 17-69 years) and 150 healthy subjects (38% male, 62% female) (age range, 19-63 years), were selected as the control group. Genotyping was performed by Tetra-ARMS-PCR method.Results: A significant difference was observed in the genotypic distribution of miR-155 rs2829803 in dominant form (OR: 0.33, 95% CI: 1.19-0.58) (p=0.0001) and heterozygote (OR: 1.92, 95% CI: 1.17-3.16) (p=0.01) in patients compared to the healthy subjects.Conclusion: In line with previous studies on the relationship between miR-155 POLYMORPHISM (rs2829803) and MULTIPLE SCLEROSIS disease, the results of this study confirmed the association of this POLYMORPHISM with increased risk of developing the disease.

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APA: Copy

ABOLFATHIRAD, SANAZ, SARI, SOYAR, & MIRFAKHRAIE, REZA. (2018). AN ASSOCIATION STUDY OF RS2829803 POLYMORPHISM IN MIRNA-155 WITH MULTIPLE SCLEROSIS IN PATIENTS REFERRED TO FARSHCHIAN HOSPITAL OF HAMADAN CITY, (IRAN). QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 12(2 ), 28-34. SID. https://sid.ir/paper/132500/en

Vancouver: Copy

ABOLFATHIRAD SANAZ, SARI SOYAR, MIRFAKHRAIE REZA. AN ASSOCIATION STUDY OF RS2829803 POLYMORPHISM IN MIRNA-155 WITH MULTIPLE SCLEROSIS IN PATIENTS REFERRED TO FARSHCHIAN HOSPITAL OF HAMADAN CITY, (IRAN). QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2018;12(2 ):28-34. Available from: https://sid.ir/paper/132500/en

IEEE: Copy

SANAZ ABOLFATHIRAD, SOYAR SARI, and REZA MIRFAKHRAIE, “AN ASSOCIATION STUDY OF RS2829803 POLYMORPHISM IN MIRNA-155 WITH MULTIPLE SCLEROSIS IN PATIENTS REFERRED TO FARSHCHIAN HOSPITAL OF HAMADAN CITY, (IRAN),” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 12, no. 2 , pp. 28–34, 2018, [Online]. Available: https://sid.ir/paper/132500/en

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