SURVEY OF MUTAGENICITY EFFECTS OF HYPIRAN ORAL DROPS

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MORADIAN TEHRANI M.

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Journal: Iranian Journal of Basic Medical Sciences Year:2002 | Volume:5 | Issue:2 (14) Page(s): 95-99

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Information Journal Paper

Title

SURVEY OF MUTAGENICITY EFFECTS OF HYPIRAN ORAL DROPS

Author(s)

MORADIAN TEHRANI M. | Issue Writer Certificate

Keywords

MUTAGENICITYQ3

HYPERICUM PERFORATUMQ3

AMES TESTQ4

Abstract

Hypericum perforatum is traditionally used for the treatment of many diseases. This oral drop drug is recommended for relief of migraine pain and is also used as an anti - depressant. In this research we surveyed MUTAGENICITY effects of Hypiran. Conducting the AMES TEST, we used Salmonella typhimurium which has mutated histidine operan and depends on histidine for its growth. The tester strains used were, TA98 and TA100 which can determine point mutations including frame shift and base pair substitution mutations. These strains can also grow and produce colonies in the presence of mutagen substances in minimal glucose agar medium. Hypiran drops were prepared in different volumes such as 10, 20, 50, 100, 200, 250 and 300 microliter and were exposed to TA98 and TA100 strains. TA98 and TA100 were cultured in media with minimum glucose agar; and the produced colonies were counted after 48 hours. The mean of revertant colonies in each group was compared with the mean of each corresponding control revertant colony. Using evaluation indices, the rates of mutation was calculated and dose -response curve plotted. Hypiran oral drops in many applied volumes can revert TA98 and TA100.It can establish point mutations including frame shift and base pair substitution mutation. Based on evaluation indices related to the AMES TEST, Hypiran drops are a mutagen. However, in order to obtain higher certainty, other MUTAGENICITY tests must be performed.

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APA: Copy

MORADIAN TEHRANI, M.. (2002). SURVEY OF MUTAGENICITY EFFECTS OF HYPIRAN ORAL DROPS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 5(2 (14)), 95-99. SID. https://sid.ir/paper/52458/en

Vancouver: Copy

MORADIAN TEHRANI M.. SURVEY OF MUTAGENICITY EFFECTS OF HYPIRAN ORAL DROPS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2002;5(2 (14)):95-99. Available from: https://sid.ir/paper/52458/en

IEEE: Copy

M. MORADIAN TEHRANI, “SURVEY OF MUTAGENICITY EFFECTS OF HYPIRAN ORAL DROPS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 5, no. 2 (14), pp. 95–99, 2002, [Online]. Available: https://sid.ir/paper/52458/en

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