PREPARATION AND EVALUATION OF PHYSICO - CHEMICAL PROPERTIES AND KINETICS MODEL OF INRET AND SUSTAINED - RELEASE DILTLAZEM HYDROCHLORIDE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOGHBEL A.; AGHELI H.; IRANI T.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2000 | Volume:3 | Issue:2 (7) Page(s): 101-108

Download Full-Text

Persian Verion

View:

1,466

Download:

Cites:

Information Journal Paper

Title

PREPARATION AND EVALUATION OF PHYSICO - CHEMICAL PROPERTIES AND KINETICS MODEL OF INRET AND SUSTAINED - RELEASE DILTLAZEM HYDROCHLORIDE

Author(s)

MOGHBEL A. | AGHELI H. | IRANI T. | Issue Writer Certificate

Keywords

PELLETIZATION TECHNOLOGYQ4

DILTIAZEM HYDROCHLORIQEQ4

EUDRAGITQ4

SUSTAINED - RELEASEQ4

Abstract

The pellets have preference over the other oral SUSTAINED - RELEASE dosage forms, because they have advantages such as desired form and good flowability, equal distribution in gastrointestinal tract and reduction of peak plasma level changes. In this study, after preparation of inert pellets using a pan and fluid bed coater machines and evaluating their characteristics, sustained-release diltiazem hydrochloride pellets were prepared. By spraying drug suspension and coating solution on inert pellets. During formulation, it was specified that factors such as instrument used, type of materials, adjust particle size of drug and the ratio of central core diameter to the drug particle diameter, are factors affecting pellet shape and quality. Finally, the formulated product was controlled quantitatively and qualitatively, and in order to determine the best drug release model, the dissolution test data were checked with the common mathematical equations. Result obtained from evaluated pellets, showed that there has been a direct relationship between bulk density of inert and medicinal pellets. However the true density of inert pellets increased with decreasing particle size of pellets. Assay for the sustained release pellets showed a good condition, since initial dose of the drug was released at the first 2 hours and the other doses were released during 24 hours, conforming USP XXIII specifications. The plasticizer had no effect on the release pattern of the pellets. Also, the study of release kinetics showed that the drug process is best described by cube root equation of Hixson-crowell.

Cites

No record.

References

No record.

Cite

APA: Copy

MOGHBEL, A., AGHELI, H., & IRANI, T.. (2000). PREPARATION AND EVALUATION OF PHYSICO - CHEMICAL PROPERTIES AND KINETICS MODEL OF INRET AND SUSTAINED - RELEASE DILTLAZEM HYDROCHLORIDE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 3(2 (7)), 101-108. SID. https://sid.ir/paper/52517/en

Vancouver: Copy

MOGHBEL A., AGHELI H., IRANI T.. PREPARATION AND EVALUATION OF PHYSICO - CHEMICAL PROPERTIES AND KINETICS MODEL OF INRET AND SUSTAINED - RELEASE DILTLAZEM HYDROCHLORIDE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2000;3(2 (7)):101-108. Available from: https://sid.ir/paper/52517/en

IEEE: Copy

A. MOGHBEL, H. AGHELI, and T. IRANI, “PREPARATION AND EVALUATION OF PHYSICO - CHEMICAL PROPERTIES AND KINETICS MODEL OF INRET AND SUSTAINED - RELEASE DILTLAZEM HYDROCHLORIDE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 3, no. 2 (7), pp. 101–108, 2000, [Online]. Available: https://sid.ir/paper/52517/en

Related Journal Papers