COMPARATIVE RANDOMIZED CLINICAL TRIAL OF DOXYCYCLIN - RIFAMPIN VERSUS DOXYCYCLIN - RIFAMPIN PLUS SEVEN DAYS AMIKACIN IN TREATMENT OF HUMAN BRUCELLSIS

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RANJBAR M.; KERAMAT F.; MAMANI M.; ROSTAMIKIA A.; KHALILIAN F.

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Title

COMPARATIVE RANDOMIZED CLINICAL TRIAL OF DOXYCYCLIN - RIFAMPIN VERSUS DOXYCYCLIN - RIFAMPIN PLUS SEVEN DAYS AMIKACIN IN TREATMENT OF HUMAN BRUCELLSIS

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Keywords

BRUCELLOSISQ2

TREATMENTQ3

HAMADANQ3

Abstract

Background: BRUCELLOSIS is a zoonosis that is a systemic infection in which any organ or system of the body can be involved. Antimicrobial therapy relives symptoms and prevents complications. The aim of this study is comparation of two TREATMENT regimens for relieves symptoms, rate of relapse, prevalence of complications.Methods: This study is a comparative randomized clinical trial Between 220 patients with BRUCELLOSIS (Complications such as meningitis and endocarditic were excluded). First group were received Doxycyclin + Rifampin (OR group) and second group were received Doxycyclin + Rifampin + Amikacin (7 days) (ADR group).The patients were evaluated for percent of response to TREATMENT, rate of relives symptoms and incidence of relapse.Results: In this study 203 cases have been response to TREATMENT, that 106 cases with ADR group and 97 cases with OR were treated (P= 0.04). The appropriated response to TREATMENT, time was shorted by ADR regimen (P=0.06). Relapse occurred in 9.3% in OR group but in 5.4% in ADR group. The complications of Drugs, were not different between two groups.Conclusion: The rate of response to TREATMENT and successful in treating was higher in ADR group than OR groups, but the complications of Drugs was not different between Two groups, So ADR regimen is a good and effective combination in TREATMENT of BRUCELLOSIS.

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APA: Copy

RANJBAR, M., KERAMAT, F., MAMANI, M., ROSTAMIKIA, A., & KHALILIAN, F.. (2005). COMPARATIVE RANDOMIZED CLINICAL TRIAL OF DOXYCYCLIN - RIFAMPIN VERSUS DOXYCYCLIN - RIFAMPIN PLUS SEVEN DAYS AMIKACIN IN TREATMENT OF HUMAN BRUCELLSIS. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 10(29), 29-34. SID. https://sid.ir/paper/52753/en

Vancouver: Copy

RANJBAR M., KERAMAT F., MAMANI M., ROSTAMIKIA A., KHALILIAN F.. COMPARATIVE RANDOMIZED CLINICAL TRIAL OF DOXYCYCLIN - RIFAMPIN VERSUS DOXYCYCLIN - RIFAMPIN PLUS SEVEN DAYS AMIKACIN IN TREATMENT OF HUMAN BRUCELLSIS. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2005;10(29):29-34. Available from: https://sid.ir/paper/52753/en

IEEE: Copy

M. RANJBAR, F. KERAMAT, M. MAMANI, A. ROSTAMIKIA, and F. KHALILIAN, “COMPARATIVE RANDOMIZED CLINICAL TRIAL OF DOXYCYCLIN - RIFAMPIN VERSUS DOXYCYCLIN - RIFAMPIN PLUS SEVEN DAYS AMIKACIN IN TREATMENT OF HUMAN BRUCELLSIS,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 10, no. 29, pp. 29–34, 2005, [Online]. Available: https://sid.ir/paper/52753/en

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