THE EFFICACY OF FURAZOLIDONE BASED QUADRUPLE THERAPY FOR ERADICATION OF H. PYLORI INFECTION IN PATIENTS RESISTANT TO METRONIDAZOLE BASED QUADRUPLE THERAPY IN IRAN

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EBRAHIMI DARYANI N.; MIRMOUMEN SH.; FARAHVASH M.; NOURMOHAMMADPOUR P.; SOTOUDEHMANESH R.

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2002 | Volume:7 | Issue:17 Page(s): 7-10

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Title

THE EFFICACY OF FURAZOLIDONE BASED QUADRUPLE THERAPY FOR ERADICATION OF H. PYLORI INFECTION IN PATIENTS RESISTANT TO METRONIDAZOLE BASED QUADRUPLE THERAPY IN IRAN

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Abstract

Background: H, pylori is strongly associated with chronic active gastritis and 95-99% of duodenal ulcers and most gastric ulcers as well. Metronidazole based therapies show an optimal efficacy ranging from 80' to 95% in western countries but in areaswitha high Metronidazole resistance such as IRAN the eradication rate is usually suboptimal. Fufazolidone shows a promising efficacy while replacing Metronidazole in different eradication regimens. This study 15 trying to determine the efficacy of a quadruple therapy based on Furazolidone as a second line treatment in Metronidazole resistant patients. Materials and methods: 89 H. pylori infectedpatients who were treated for at least 14 days with Metronidazole based quadruple therapy and still had a positive UBT had been included. They were treated with Furazolidone, Bismuth, Amoxicilline and Omeprazole for 2 weeks. Eradication was described as negative 14 C-Urease Breath test, 4 to 6 weeks after of the treatment. Results: Total eradication rate in 89 patients who completed the treatment course was 68/89 (75.6%) Eradication rate has not significant relationship with gender of patients (35/48 in males versus 35/41 in females, P > 0.05). 19 patients out of 90 (21.1%) were smoker. Eradication rate among smokers was 11/19 and in non-smokers was 57/70 (P < 0.05) and there was a significant relationship between smoking and decrease of eradication rate (Ci > 95% & OR = 3.12). Distribution of H. pylori associated problem in our patients (determined) by endoscopy) was duodenal ulcer (DU) (11.1%) and nonulcer dyspepsia (NUD) (10%). Eradication rate was different in these groups: in DU patients 55/70, in GU patients 6/10 and in NOD patients 7/9(P>0.05). Therefore we couldn't show any significant relation between these items.Discussion: This study determines the efficacy of a quadruple therapy regimen based on Furazolidone as a second line treatment. So in Iran, where Claritromycin is very expensive and difficult to archive, Furasolidone could be used sufficiently.

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APA: Copy

EBRAHIMI DARYANI, N., MIRMOUMEN, SH., FARAHVASH, M., NOURMOHAMMADPOUR, P., & SOTOUDEHMANESH, R.. (2002). THE EFFICACY OF FURAZOLIDONE BASED QUADRUPLE THERAPY FOR ERADICATION OF H. PYLORI INFECTION IN PATIENTS RESISTANT TO METRONIDAZOLE BASED QUADRUPLE THERAPY IN IRAN. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 7(17), 7-10. SID. https://sid.ir/paper/52789/en

Vancouver: Copy

EBRAHIMI DARYANI N., MIRMOUMEN SH., FARAHVASH M., NOURMOHAMMADPOUR P., SOTOUDEHMANESH R.. THE EFFICACY OF FURAZOLIDONE BASED QUADRUPLE THERAPY FOR ERADICATION OF H. PYLORI INFECTION IN PATIENTS RESISTANT TO METRONIDAZOLE BASED QUADRUPLE THERAPY IN IRAN. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2002;7(17):7-10. Available from: https://sid.ir/paper/52789/en

IEEE: Copy

N. EBRAHIMI DARYANI, SH. MIRMOUMEN, M. FARAHVASH, P. NOURMOHAMMADPOUR, and R. SOTOUDEHMANESH, “THE EFFICACY OF FURAZOLIDONE BASED QUADRUPLE THERAPY FOR ERADICATION OF H. PYLORI INFECTION IN PATIENTS RESISTANT TO METRONIDAZOLE BASED QUADRUPLE THERAPY IN IRAN,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 7, no. 17, pp. 7–10, 2002, [Online]. Available: https://sid.ir/paper/52789/en

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