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Information Journal Paper

Title

IMMUNE RESPONSE TO STANDARD DOSE OF HEPATITIS B VACCINE IN HIV PATIENTS IN CONSULTING CENTER OF KERMANSHAH IN 1383

Pages

  9-14

Abstract

 Background and objectives: HEPATITIS B infection is a major problem in HIV Patients. Because of similar port of transmission, all of HIV patients are at risk to acquisition of HBV infection. The major way for prevention of HBV infection is VACCINATION against HBV. In this study the seroconversion rate to HBV VACCINATION in HIV Patients referred to consulting center of KERMANSHAH, was evaluated. Material and methods: In this cross sectional study, 169 HIV Patients who were HBs-Ag and HBc-Ab negative ,vaccinated against HEPATITIS B viruses (20 μg of recombinant HBsAg at 0-1-6 mo schedule in deltoid region) in 2004 .We measured anti-HBs titer 30 days after delivery of the third dose. Patients with titer above 10μIu/ml considered immune. Some factors included: Age, Sex, IVD using, hepatitis C coinfection, CD4 count, evaluated and data,s analyzed using X2 test. Results: Among 169 HIV Patients (157 males, 12 females) immune response rate was 52/7%, this rate was 66/7 % and 51/9% for female and male group respectively ( NS). Immune response was 54.3%, 44.3% and 45.3% in CD4 count >500,200-499 and <200 respectively (P<0.039). In antiretroviral treated group response rate was 81.8% (P<0.045). Immune response rate was 51% in IVDU's and 51.3% in HCV co infected individuals (PV=0.294%). Conclusion: In this study immune response rate to HBV vaccine was similar to most other studies. We demonstrated that two factors included Antecedent anti retroviral therapy and CD4 count were associated with seroconversion rate ,Thus we recommend that VACCINATION against HBV in early phase of HIV infection that CD4 count was not significantly reduced and during of anti retroviral therapy, could improve response rate to HBV vaccine.

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    APA: Copy

    JANBAKHSH, A.R., VAZIRI, S., SAYAD, B., AFSHARIAN, MANDANA, REZAIE, M., & MONTAZERIPOUR, H.. (2006). IMMUNE RESPONSE TO STANDARD DOSE OF HEPATITIS B VACCINE IN HIV PATIENTS IN CONSULTING CENTER OF KERMANSHAH IN 1383. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 11(33), 9-14. SID. https://sid.ir/paper/52835/en

    Vancouver: Copy

    JANBAKHSH A.R., VAZIRI S., SAYAD B., AFSHARIAN MANDANA, REZAIE M., MONTAZERIPOUR H.. IMMUNE RESPONSE TO STANDARD DOSE OF HEPATITIS B VACCINE IN HIV PATIENTS IN CONSULTING CENTER OF KERMANSHAH IN 1383. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2006;11(33):9-14. Available from: https://sid.ir/paper/52835/en

    IEEE: Copy

    A.R. JANBAKHSH, S. VAZIRI, B. SAYAD, MANDANA AFSHARIAN, M. REZAIE, and H. MONTAZERIPOUR, “IMMUNE RESPONSE TO STANDARD DOSE OF HEPATITIS B VACCINE IN HIV PATIENTS IN CONSULTING CENTER OF KERMANSHAH IN 1383,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 11, no. 33, pp. 9–14, 2006, [Online]. Available: https://sid.ir/paper/52835/en

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