FORMULATION, CHARACTERIZATION AND RELEASE STUDIES OF ALGINATE MICROSPHERES ENCAPSULATED WITH TETANUS TOXOID FOR NASAL IMMUNIZATION

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TAFAGHODI M.; SAJADI TABASSI S.A.; JAFARI M.R.

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Journal: Iranian Journal of Basic Medical Sciences Year:2003 | Volume:6 | Issue:1 (17) Page(s): 20-31

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Title

FORMULATION, CHARACTERIZATION AND RELEASE STUDIES OF ALGINATE MICROSPHERES ENCAPSULATED WITH TETANUS TOXOID FOR NASAL IMMUNIZATION

Author(s)

TAFAGHODI M. | SAJADI TABASSI S.A. | JAFARI M.R. | Issue Writer Certificate

Keywords

ALGINATEQ2

MICROSPHEREQ4

MUCOSAL DELIVERYQ4

TETANUS TOXOIDQ4

Abstract

ALGINATE is a safe, non-immunogenic and inexpensive natural polymer with high mucoadhesive properties. ALGINATE MICROSPHEREs can be used as a delivery system for antigens to the mucosal surfaces. ALGINATE MICROSPHEREs were prepared by emulsification-internal phase gelation. Effects of different sonication times; ALGINATE, emulsifier and calcium concentrations; and the volume of calcium solution on mean size, size range, surface roughness and porosity, sphericity and clumping of MICROSPHEREs were evaluated using optical microscope and zetasizer. The best conditionswere resulted by 90 sec. sonication, 3% ALGINATE solution, 2% surfactant, and 60 ml of 0.33% CaCl2 in octanol. The resulting MICROSPHEREs had mean size of 1.34±0.3 μm (n=3) and size range of 0.3 - 2.0 μm with no surface roughness and porosity, low clumping and high sphericity. The encapsulation rate was about 47.7% (n=6). All batches showed nearly the same release profiles with a low burst release. The intacticity of model antigen (TETANUS TOXOID=TT) extracted from MICROSPHEREs was confirmed by SDS-PAGE and the antigenicity of TT was studied by ELISA and found to be 91±5% that of the original TT. With regard to the size and morphological characteristics of the prepared MICROSPHEREs and preservation of the antigenicity of the encapsulated TT, they could be used as a delivery system for MUCOSAL DELIVERY of TT.

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APA: Copy

TAFAGHODI, M., SAJADI TABASSI, S.A., & JAFARI, M.R.. (2003). FORMULATION, CHARACTERIZATION AND RELEASE STUDIES OF ALGINATE MICROSPHERES ENCAPSULATED WITH TETANUS TOXOID FOR NASAL IMMUNIZATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 6(1 (17)), 20-31. SID. https://sid.ir/paper/357326/en

Vancouver: Copy

TAFAGHODI M., SAJADI TABASSI S.A., JAFARI M.R.. FORMULATION, CHARACTERIZATION AND RELEASE STUDIES OF ALGINATE MICROSPHERES ENCAPSULATED WITH TETANUS TOXOID FOR NASAL IMMUNIZATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2003;6(1 (17)):20-31. Available from: https://sid.ir/paper/357326/en

IEEE: Copy

M. TAFAGHODI, S.A. SAJADI TABASSI, and M.R. JAFARI, “FORMULATION, CHARACTERIZATION AND RELEASE STUDIES OF ALGINATE MICROSPHERES ENCAPSULATED WITH TETANUS TOXOID FOR NASAL IMMUNIZATION,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 6, no. 1 (17), pp. 20–31, 2003, [Online]. Available: https://sid.ir/paper/357326/en

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