PLASMA LEVELS OF VITAMIN E AND MALONDIALDEHYDE IN AGE-RELATED CATARACT

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RAHBANI NOUBAR M.B.; NOURI M.; RAHBANI NOUBAR M.; RASHIDI M.R.; SAJADI S.A.

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2003 | Volume:- | Issue:58 Page(s): 21-25

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Title

PLASMA LEVELS OF VITAMIN E AND MALONDIALDEHYDE IN AGE-RELATED CATARACT

Author(s)

RAHBANI NOUBAR M.B. | NOURI M. | RAHBANI NOUBAR M. | RASHIDI M.R. | SAJADI S.A.

Keywords

VITAMIN E

MALONDIALDEHYDE

CATARACT

FREE RADICALS

BMI

Abstract

Background and Objectives: Age-related cataract is the main cause of blindness and visual impairment throughout the world. Biochemical evidences suggest that oxidative stress caused accumulation of free radicals is involved in the pathogenesis of the cataract. Epidemiologic studies suggest that the use of vitamin supplements, especially vitamin E, reduces risk of the cataract. The study was carried out to measure the plasma levels of vitamin E and malondialdehyde (MDA), the marker of oxidative stress, in subjects suffering from cataract and to show any relationship between the parameters and body mass index (BMI) in the patients and controls.
Materials and Methods: Plasma levels of Vitamin E and MDA were measured in 100 patients (55 males and 45 females) with cataract and results were compared with those obtained from 100 sex- and age-matched apparently healthy individuals as control group. The correlations between the measured parameters and BMI were evaluated. The plasma levels of vitamin E were measured by high performance liquid chromatography (HPLC) and that of MDA by spectrophotometry method using thiobarbituric acid reaction.
Results: Comparing the mean plasma levels of vitamin E in the patients (8.86, µg/ml) with those of controls (9.87, µg/ml), significant reduction (P<0.05) was observed in the patients. Marked elevation in the plasma levels of MDA in the patients (2.71, µmol/L) in comparison with those of controls (2.17, µmol/l) was found (P<0.05). Correlation coefficients between vitamin E and BMI in the patients and control group were 0.28 (P<0.01) and 0.45 (P<0.01) respectively, indicating receipt of more vitamin E with high energy intake. Regression coefficients between plasma levels of vitamin E and MDA in patients and controls were r=0.3 (P<0.05) and r=0.45 (P<0.05) respectively.
Conclusion: In view of oxidative stress in cataract it can be concluded that supplementary vitamin E may be useful in prevention of cataract in high risk individuals.

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APA: Copy

RAHBANI NOUBAR, M.B., NOURI, M., RAHBANI NOUBAR, M., RASHIDI, M.R., & SAJADI, S.A.. (2003). PLASMA LEVELS OF VITAMIN E AND MALONDIALDEHYDE IN AGE-RELATED CATARACT. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, -(58), 21-25. SID. https://sid.ir/paper/532315/en

Vancouver: Copy

RAHBANI NOUBAR M.B., NOURI M., RAHBANI NOUBAR M., RASHIDI M.R., SAJADI S.A.. PLASMA LEVELS OF VITAMIN E AND MALONDIALDEHYDE IN AGE-RELATED CATARACT. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2003;-(58):21-25. Available from: https://sid.ir/paper/532315/en

IEEE: Copy

M.B. RAHBANI NOUBAR, M. NOURI, M. RAHBANI NOUBAR, M.R. RASHIDI, and S.A. SAJADI, “PLASMA LEVELS OF VITAMIN E AND MALONDIALDEHYDE IN AGE-RELATED CATARACT,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. -, no. 58, pp. 21–25, 2003, [Online]. Available: https://sid.ir/paper/532315/en

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