A STUDY OF CELLULAR PROLIFERATION INDEX (KI-67 PROTEIN) IN MENINGIOMAS AND ITS COMPARISON IN BENIGN, ATYPICAL AND ANAPLASTIC MENINGIOMAS

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MAHZOUNI P.; HEIDARPOOR M.

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL Year:2004 | Volume:21 | Issue:73(Special Issue) Page(s): 18-21

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Title

A STUDY OF CELLULAR PROLIFERATION INDEX (KI-67 PROTEIN) IN MENINGIOMAS AND ITS COMPARISON IN BENIGN, ATYPICAL AND ANAPLASTIC MENINGIOMAS

Author(s)

MAHZOUNI P. | HEIDARPOOR M.

Keywords

MENINGIOMA

IMMUNOHISTOCHEMICAL

KI-67 PROTEIN

Abstract

INTRODUCTION: Meningiomas account for 20% of intracranial tumors and most of them are benign. Meningiomas are histologically classified into 3 different World Health Organization (WHO) grades: grade 1 (benign), grade 2 (atypical), grade3 (anaplastic). Atypical and anaplastic meningiomas are defined by various histological criteria in hematoxylin and eosin (H & E) staining. However, these histologic criteria are sometimes insufficient and other criteria are necessary. Ki-67 (also known as MIB-1) is a monoclonal antibody staining agent, which is routinely used as a marker of cellular proliferation. METHODS: We studied and analyzed the immunohistochemical expression of Ki-67 protein in 70 cases of meningioma, including 56 benign, 5 atypical, and 9 anaplastic meningiomas. RESULTS: According to the percentage of MIB-1 positively stained cells, meningiomas were divided into 3 groups: S1% (n=49), 1.1-9.9% (n=13) and >=10% (n=8). We found the MIB-1labeling index (LI) less than 1% in 49 (87.5%) grade 1 meningiomas. On the other hand, 7 (77.7%) grade 3 meningiomas presented a MIB-1 LI more than 10%. Most of the benign meningiomas express low MIB-1 LI (mean: 1.5%). In contrast, the anaplastic types had a high MIB-1 LI (mean: 14.2%). The atypical meningiomas had MIB-1 LI in the range between benign and anaplastic types (mean: 8.6%). These differences were statistically significant among benign, atypical, and anaplastic meningiomas (P<0.001). DISCUSSION: The immunohistochemistry of Ki-67 protein (MIB-1) is valuable in determining the grade of meningiomas in histologically borderline cases.

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APA: Copy

MAHZOUNI, P., & HEIDARPOOR, M.. (2004). A STUDY OF CELLULAR PROLIFERATION INDEX (KI-67 PROTEIN) IN MENINGIOMAS AND ITS COMPARISON IN BENIGN, ATYPICAL AND ANAPLASTIC MENINGIOMAS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 21(73(Special Issue)), 18-21. SID. https://sid.ir/paper/534541/en

Vancouver: Copy

MAHZOUNI P., HEIDARPOOR M.. A STUDY OF CELLULAR PROLIFERATION INDEX (KI-67 PROTEIN) IN MENINGIOMAS AND ITS COMPARISON IN BENIGN, ATYPICAL AND ANAPLASTIC MENINGIOMAS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2004;21(73(Special Issue)):18-21. Available from: https://sid.ir/paper/534541/en

IEEE: Copy

P. MAHZOUNI, and M. HEIDARPOOR, “A STUDY OF CELLULAR PROLIFERATION INDEX (KI-67 PROTEIN) IN MENINGIOMAS AND ITS COMPARISON IN BENIGN, ATYPICAL AND ANAPLASTIC MENINGIOMAS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 21, no. 73(Special Issue), pp. 18–21, 2004, [Online]. Available: https://sid.ir/paper/534541/en

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