PREVENTIVE EFFECT OF HYDROALCOHOLIC CYNARA SCOLYMUS EXTRACT ON APPEARANCE OF TYPE 1 DIABETES MELLITUS IN MALE RATS

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AHMADI MAHMOUDABADI NARGOL; MADANI H.; VAHDATI A.; MAHZOUNI P.

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Journal: Iranian Journal of Diabetes and Metabolism Year:2006 | Volume:6 | Issue:1 Page(s): 37-44

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Title

PREVENTIVE EFFECT OF HYDROALCOHOLIC CYNARA SCOLYMUS EXTRACT ON APPEARANCE OF TYPE 1 DIABETES MELLITUS IN MALE RATS

Author(s)

AHMADI MAHMOUDABADI NARGOL | MADANI H. | VAHDATI A. | MAHZOUNI P. | Issue Writer Certificate

Keywords

TYPE 1 DIABETES MELLITUSQ3

CYNARA SCOLYMUSQ3

ALLOXAN MONOHYDRATEQ3

GLIBENCLAMIDEQ3

Abstract

Background: Artichoke with the scientific name of CYNARA SCOLYMUSe is a plant from compositae family. In this research, the effect of hydro alcoholic artichoke extract on serum glucose, lipids and lipoproteins and prevention of TYPE 1 DIABETES MELLITUS was investigated. Methods: Twenty mature male Rats with mean weight of 200-250 gr in four groups were arranged. Rats in the control group, received physiological serum. The Second group (diabetic) received 120 mg/kgbw ALLOXAN MONOHYDRATE. The Third group (diabetic + GLIBENCLAMIDE) received 0.5 mg/kgbw GLIBENCLAMIDE in addition of the similar treatment with second group. The Fourth group (Alloxan monohydrate + CYNARA SCOLYMUS), received 120 mg/kgbw ALLOXAN MONOHYDRATE with 300 mg/kgbw of CYNARA SCOLYMUS simultaneously. Prescribing materials in all groups was done as interaperitoneal injection(IP). Fourty eight hours after last IP, blood sample was taken from each animal via cardiac puncture to measure blood factors. Results: The results indicated significant reduction in glucose, cholesterol, triglyceride, VLDL and LDL levels in the treated group with extract and ALLOXAN MONOHYDRATE simultaneously as to compared diabetic group. Also, the result indicated significant increase in HDL level. Hydroalcoholic Artichoke extract could not reduce blood glucose level as compared with GLIBENCLAMIDE, but had similar effects on other factors in comparison with Glibenclomide. Conclusion: Artichoke contains antioxidants compounds, that plays a protective role on beta cells against Alloxan. The results of this research indicate that hydro alcoholic extract of CYNARA SCOLYMUS could effectively prevent TYPE 1 DIABETES MELLITUS.

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References

PHARMACOGNOSICAL & PLANT TISSUE CULTURE STUDIES OF MELISSA OFFICINALIS L

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APA: Copy

AHMADI MAHMOUDABADI, NARGOL, MADANI, H., VAHDATI, A., & MAHZOUNI, P.. (2006). PREVENTIVE EFFECT OF HYDROALCOHOLIC CYNARA SCOLYMUS EXTRACT ON APPEARANCE OF TYPE 1 DIABETES MELLITUS IN MALE RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 6(1), 37-44. SID. https://sid.ir/paper/53978/en

Vancouver: Copy

AHMADI MAHMOUDABADI NARGOL, MADANI H., VAHDATI A., MAHZOUNI P.. PREVENTIVE EFFECT OF HYDROALCOHOLIC CYNARA SCOLYMUS EXTRACT ON APPEARANCE OF TYPE 1 DIABETES MELLITUS IN MALE RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2006;6(1):37-44. Available from: https://sid.ir/paper/53978/en

IEEE: Copy

NARGOL AHMADI MAHMOUDABADI, H. MADANI, A. VAHDATI, and P. MAHZOUNI, “PREVENTIVE EFFECT OF HYDROALCOHOLIC CYNARA SCOLYMUS EXTRACT ON APPEARANCE OF TYPE 1 DIABETES MELLITUS IN MALE RATS,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 6, no. 1, pp. 37–44, 2006, [Online]. Available: https://sid.ir/paper/53978/en

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