DETERMINANTS OF TOTAL PLASMA HOMOCYSTEINE CONCENTRATION IN HEALTHY IRANIAN ADULTS: THE TEHRAN HOMOCYSTEINE SURVEY (2003-2004)

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GHOTBI SARA; HESHMAT RAMIN; POUR-EBRAHIM R.; NOURI M.; SHAFAEE A.R.; ARDESHIR LARIJANI MOHAMMAD BAGHER; FAKHRZADEH H.

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Journal: Iranian Journal of Diabetes and Metabolism Year:2005 | Volume:5 | Issue:2 Page(s): 163-174

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Title

DETERMINANTS OF TOTAL PLASMA HOMOCYSTEINE CONCENTRATION IN HEALTHY IRANIAN ADULTS: THE TEHRAN HOMOCYSTEINE SURVEY (2003-2004)

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Keywords

HOMOCYSTEINEQ3

DETERMINANTS OF THCYQ4

CARDIOVASCULAR DISEASEQ4

AGEQ3

SEXQ3

Abstract

Background: Elevated total plasma HOMOCYSTEINE, is an independent risk factor for CARDIOVASCULAR DISEASE. Folate and vitamin B12 have not only a protective effect on CARDIOVASCULAR DISEASE but also an essential effect on total HOMOCYSTEINE concentrations (tHcy). This survey has been conducted to evaluate the DETERMINANTS OF THCY in 1191 healthy Iranian adults. Methods: This study which was a part of the Cardiovascular Risk Factors Survey in the Population Lab Region, has been designed and conducted based on MONICA/WHO project. A total of 1191 people have been recruited and assessed on serum HOMOCYSTEINE, Folic acid and vitamin B12, triglycerides, cholesterol, HDL-C, LDL-C, FBS, BMI, BP and smoking, with interview, questionnaires, examination and blood sampling. Blood samples were analyzed according to standard methods. Results: The variables were assessed in 1191 participants include 416 men (34.9%) and 775 women (65.1%). Prevalence of hyperHOMOCYSTEINEmia was correlated significantly with male SEX and aging. Hcy levels were inversely related to serum Folate and vitamin B12 concentrations. After further adjustments, we detected a positive correlation between tHcy and AGE, male SEX, smoking and BMI, and a negative one with LDL-C and diabetes. Although there was a correlation between tHcy and blood pressure, after AGE, SEX, BMI and smoking adjustment, it just remained significant in women and with systolic blood pressure. ‍Conclusion: We found that dietary and lifestyle parameters such as Folate intake and smoking habit are the main determinants of distribution of plasma HOMOCYSTEINE in an apparently healthy population. We assumed that lifestyle changes could have considerable subsequences in public health. Our findings confirm the potential advantages of dietary improvements and increased intake of nutrients along with smoking cessation in order to prevent CARDIOVASCULAR DISEASEs in high-risk patients.

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APA: Copy

GHOTBI, SARA, HESHMAT, RAMIN, POUR-EBRAHIM, R., NOURI, M., SHAFAEE, A.R., ARDESHIR LARIJANI, MOHAMMAD BAGHER, & FAKHRZADEH, H.. (2005). DETERMINANTS OF TOTAL PLASMA HOMOCYSTEINE CONCENTRATION IN HEALTHY IRANIAN ADULTS: THE TEHRAN HOMOCYSTEINE SURVEY (2003-2004). JOURNAL OF DIABETES AND METABOLIC DISORDERS, 5(2), 163-174. SID. https://sid.ir/paper/54032/en

Vancouver: Copy

GHOTBI SARA, HESHMAT RAMIN, POUR-EBRAHIM R., NOURI M., SHAFAEE A.R., ARDESHIR LARIJANI MOHAMMAD BAGHER, FAKHRZADEH H.. DETERMINANTS OF TOTAL PLASMA HOMOCYSTEINE CONCENTRATION IN HEALTHY IRANIAN ADULTS: THE TEHRAN HOMOCYSTEINE SURVEY (2003-2004). JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2005;5(2):163-174. Available from: https://sid.ir/paper/54032/en

IEEE: Copy

SARA GHOTBI, RAMIN HESHMAT, R. POUR-EBRAHIM, M. NOURI, A.R. SHAFAEE, MOHAMMAD BAGHER ARDESHIR LARIJANI, and H. FAKHRZADEH, “DETERMINANTS OF TOTAL PLASMA HOMOCYSTEINE CONCENTRATION IN HEALTHY IRANIAN ADULTS: THE TEHRAN HOMOCYSTEINE SURVEY (2003-2004),” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 5, no. 2, pp. 163–174, 2005, [Online]. Available: https://sid.ir/paper/54032/en

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