INVESTIGATION ON TWO POLYMORPHISMS EFFECTIVE ON HDL-C CONCENTRATION IN PATIENTS WITH CORONARY ARTERY DISEASE USING RESTRICTION FRAGMENT LENGTH POLYMORPHISM

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GHATREH SAMANI K.; NOURI MOHAMMAD; RAHBANI NOUBAR M.; HASHEMZADEH CHALESHTORI M.; FAROKHI EFAT; DARABI AMIN MASOUD

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Journal: Journal of Shahrekord University of Medical Sciences Year:2008 | Volume:10 | Issue:2 Page(s): 1-12

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Title

INVESTIGATION ON TWO POLYMORPHISMS EFFECTIVE ON HDL-C CONCENTRATION IN PATIENTS WITH CORONARY ARTERY DISEASE USING RESTRICTION FRAGMENT LENGTH POLYMORPHISM

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Keywords

CHOLESTERYL ESTER TRANSFER PROTEINQ3

CORONARY ARTERY DISEASEQ3

HEPATIC LIPASEQ3

HDL-CQ3

RESTRICTION ENZYMEQ3

Abstract

Background and aim: High density lipoprotein cholesterol (HDL-C) is a known inverse predictor of coronary heart disease (CHD). CHOLESTERYL ESTER TRANSFER PROTEIN (CEIP) and HEPATIC LIPASE (HL) are key proteins in HDL-C metabolism so that decreased CEIP or HL activity is associated with high HDL-C. -629C/A polymorphism in promoter of CEIP geneand-514C/T in promoter of HL gene were previously reported to reduce related protein level in plasma. In this study association of these polymorphisms with CHD related to HDL-C level were investigated. Methods: In this analytical-descriptive study 321 subjects underwent coronary angiography and divided in two groups base on angiogram (non CAD = 135 and CAD = 186). Serum lipids profile was measured by standard procedure and genotype was detected using PCR-RFLP method. Results: Overall the CETP genotype frequencies were in CAD patients: 58.8% (n=110), 28.9% (n=54) and 12.3% (n=23) and in non CAD patients: 45.2% (n=61), 41.5% (n=56) and 13.3% (n=18) for AA, CA and CC respectively. HL genotype frequencies were in CAD patients: 61.6% (n=114), 33.5% (n=62) and 4.9% (n=9) and in non CAD patients: 65.9% (n=89), 27.4% (n=37) and 6.7% (n=9) for CC, CT and TT respectively. In control group HDL-C concentration was higher for AA than CC genotype in -629C/A, and also for IT than CC genotype in -514Crr. Allele A in all subjects and T allele in woman were higher in CAD than non CAD group. A high increase in HDL-C level (10. mg/dl) was observed in individuals with CETP-ANLIPC-IT and CETP-CA/LIPC-IT relative to CETP-CC/LIPC-CC across all subjects (P< 0.001) but there was no difference in CAD prevalence.Conclusion: Allele A from -629C/A, and T from -514C/T even with the increasing of HDL-C concentration had higher frequency in CAD than non CAD group. Therefore, it seems that HDL-C didn't protect coronary artery when CETP or HL activity was reduced by these polymorphisms.

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APA: Copy

GHATREH SAMANI, K., NOURI, MOHAMMAD, RAHBANI NOUBAR, M., HASHEMZADEH CHALESHTORI, M., FAROKHI, EFAT, & DARABI AMIN, MASOUD. (2008). INVESTIGATION ON TWO POLYMORPHISMS EFFECTIVE ON HDL-C CONCENTRATION IN PATIENTS WITH CORONARY ARTERY DISEASE USING RESTRICTION FRAGMENT LENGTH POLYMORPHISM. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 10(2), 1-12. SID. https://sid.ir/paper/58078/en

Vancouver: Copy

GHATREH SAMANI K., NOURI MOHAMMAD, RAHBANI NOUBAR M., HASHEMZADEH CHALESHTORI M., FAROKHI EFAT, DARABI AMIN MASOUD. INVESTIGATION ON TWO POLYMORPHISMS EFFECTIVE ON HDL-C CONCENTRATION IN PATIENTS WITH CORONARY ARTERY DISEASE USING RESTRICTION FRAGMENT LENGTH POLYMORPHISM. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;10(2):1-12. Available from: https://sid.ir/paper/58078/en

IEEE: Copy

K. GHATREH SAMANI, MOHAMMAD NOURI, M. RAHBANI NOUBAR, M. HASHEMZADEH CHALESHTORI, EFAT FAROKHI, and MASOUD DARABI AMIN, “INVESTIGATION ON TWO POLYMORPHISMS EFFECTIVE ON HDL-C CONCENTRATION IN PATIENTS WITH CORONARY ARTERY DISEASE USING RESTRICTION FRAGMENT LENGTH POLYMORPHISM,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 10, no. 2, pp. 1–12, 2008, [Online]. Available: https://sid.ir/paper/58078/en

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