FACTOR XIIIA-V34L AND FACTOR XIIIB-H95R GENE POLYMORPHISMS IN SHAHREKORD, 2010, I.R. IRAN

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POURGHEYSARI B.; BESHKAR P.; AZADEGAN F.

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Title

FACTOR XIIIA-V34L AND FACTOR XIIIB-H95R GENE POLYMORPHISMS IN SHAHREKORD, 2010, I.R. IRAN

Author(s)

POURGHEYSARI B. | BESHKAR P. | AZADEGAN F. | Issue Writer Certificate

Keywords

FACTOR XIII-AV34L POLYMORPHISMQ2

FACTOR XIII-BH95R POLYMORPHISM VENOUS THROMBOEMBOLISMQ2

Abstract

Background and aims: Some of the inherited coagulation factor polymorphisms have been related to the pathogenesis of venous thromboembolism and other adverse outcomes. As there are limited data on the prevalence of these polymorphisms in Iranian populations this study aimed to assess two factor XIII polymorphisms, FXIIIA-V34L and FXIIIB-H95R, in healthy individuals.Methods: In this cross sectional study 150 healthy blood donors from Shahrekord, Iran with no history of venous thromboembolism were recruited to the study. Genotyping from EDTA taken venous blood for the above polymorphisms was under taken by PCR-RFLP.Results: Fifty one (34%) of participants were heterozygous for VL and 7 (4.67%) were homozygous LL.26 (17.33%) and 1 (0.67%) were heterozygous and homozygous for RH and RR of FXIIIB respectively.48.67% of the study population carried at least one of the above polymorphisms and there was no carrier of both as homozygous.Conclusion: The prevalence of these FXIII polymorphisms in healthy subjects is somehow similar to previously published data in Caucasian populations, but quite different than limited existing data from China and other ethnic groups. Such findings could be relevant to the ethnic similarities and differences.

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APA: Copy

POURGHEYSARI, B., BESHKAR, P., & AZADEGAN, F.. (2012). FACTOR XIIIA-V34L AND FACTOR XIIIB-H95R GENE POLYMORPHISMS IN SHAHREKORD, 2010, I.R. IRAN. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 14(3), 100-107. SID. https://sid.ir/paper/58219/en

Vancouver: Copy

POURGHEYSARI B., BESHKAR P., AZADEGAN F.. FACTOR XIIIA-V34L AND FACTOR XIIIB-H95R GENE POLYMORPHISMS IN SHAHREKORD, 2010, I.R. IRAN. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;14(3):100-107. Available from: https://sid.ir/paper/58219/en

IEEE: Copy

B. POURGHEYSARI, P. BESHKAR, and F. AZADEGAN, “FACTOR XIIIA-V34L AND FACTOR XIIIB-H95R GENE POLYMORPHISMS IN SHAHREKORD, 2010, I.R. IRAN,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 3, pp. 100–107, 2012, [Online]. Available: https://sid.ir/paper/58219/en

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