ANTINOCICEPTIVE EFFECT OF ALLIUM SCHOENOPRASUM L. ORAL FEEDING IN MALE DIABETIC RATS

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ROGHANI MEHRDAD; BALUCHNEJADMOJARAD TOURANDOKHT

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Journal: Journal of Shahrekord University of Medical Sciences Year:2011 | Volume:12 | Issue:4 Page(s): 64-70

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Title

ANTINOCICEPTIVE EFFECT OF ALLIUM SCHOENOPRASUM L. ORAL FEEDING IN MALE DIABETIC RATS

Author(s)

ROGHANI MEHRDAD | BALUCHNEJADMOJARAD TOURANDOKHT | Issue Writer Certificate

Keywords

ALLIUM SCHOENOPRASUMQ3

ANTINOCICEPTIONQ2

DIABETES MELLITUSQ2

FORMALIN TESTQ3

TAIL IMMERSION TESTQ3

Abstract

Background and aim: Hyperalgesia is considered as one of the marked signs of subchronic DIABETES MELLITUS that could affect the life style of the patients. This study was designed to investigate the antinociceptive effect of chronic feeding of ALLIUM SCHOENOPRASUM (AS) leaf in streptozotocindiabetic rats using formalin and TAIL IMMERSION TESTs. Methods: Rats were divided into control, AS leaf-treated control, diabetic, sodium salicylate (SS)-treated diabetic, and AS leaf-treated diabetic groups. The treatment groups received oral administration of AS leaf-mixed pelleted food (3%) for 8 weeks. Finally hyperalgesia were assessed using standard formalin and TAIL IMMERSION TESTs. Averaged pain score for the first 0-10 min and the later 16-60 min after formalin injection was regarded as acute and chronic phases, respectively. Results: AS leaf treatment of diabetic rats reduced pain score in chronic phase of FORMALIN TEST from 2.41±0.14 to 2.01±0.12 (P<0.05). Regarding hot TAIL IMMERSION TEST, diabetic rats showed a significant reduction (5.9 s) in tail flick latency as compared to control ones (P<0.05). However, AS leaf treatment of diabetic rats did not significantly increase this latency relative to untreated diabetics.Conclusion: Taken together, 8-week administration of AS leaf could attenuate nociceptive score in chronic phase of FORMALIN TEST in streptozotocin-induced experimental model of DIABETES MELLITUS, but, had no effect on thermal pain. Perhaps, the anti-inflammatory property of the plant is responsible for its analgesic effect.

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APA: Copy

ROGHANI, MEHRDAD, & BALUCHNEJADMOJARAD, TOURANDOKHT. (2011). ANTINOCICEPTIVE EFFECT OF ALLIUM SCHOENOPRASUM L. ORAL FEEDING IN MALE DIABETIC RATS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 12(4), 64-70. SID. https://sid.ir/paper/58242/en

Vancouver: Copy

ROGHANI MEHRDAD, BALUCHNEJADMOJARAD TOURANDOKHT. ANTINOCICEPTIVE EFFECT OF ALLIUM SCHOENOPRASUM L. ORAL FEEDING IN MALE DIABETIC RATS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;12(4):64-70. Available from: https://sid.ir/paper/58242/en

IEEE: Copy

MEHRDAD ROGHANI, and TOURANDOKHT BALUCHNEJADMOJARAD, “ANTINOCICEPTIVE EFFECT OF ALLIUM SCHOENOPRASUM L. ORAL FEEDING IN MALE DIABETIC RATS,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 12, no. 4, pp. 64–70, 2011, [Online]. Available: https://sid.ir/paper/58242/en

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