EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF ARTEMISIA AUCHERI ON CASTOR OILINDUCED DIARRHEA IN MALE RAT

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HAKIMIZADEH E.; ASKARY A.; SHAMSIZADEH A.; RAHMANI M.R.; VAZIRINEJAD R.; AYOOBI F.; AMIN F.; REZAZADEH H.A.; KAMALI B.; ALLAHTAVAKOLI M.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2013 | Volume:15 | Issue:3 Page(s): 1-8

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Title

EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF ARTEMISIA AUCHERI ON CASTOR OILINDUCED DIARRHEA IN MALE RAT

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ARTEMISIA AUCHERIQ3

DIARRHEAQ2

RATQ2

Abstract

Background and aims: DIARRHEA is one of the worldwide health problems and also one of the most common causes of children’s death. In this study the effect of ARTEMISIA AUCHERI on castor oil-induced DIARRHEA was investigated.Methods: In this experimental study 30 male RATs were randomly divided into 5 groups as flowing: group receiving.ARTEMISIA AUCHERI in doses of 50, 100 and 200 mg/kg, Diphenoxylate 5 mg/kg; and control group solvent (Physiology cerum). One hour after drugs orally receiving or (normal saline 10 ml/kg), each animal was given castor oil (2 ml/rat) by an oro-gastric catheter.Then the RAT's defection was placed in to a separate cage and observed for 5 h to determine fecal quality, frequency, and weight. Data were analyzed useing one-way ANOVA and Tukey tests and P<0.05 was considered as significant difference.Results: ARTEMISIA AUCHERI in doses of 100 and 200 and Diphenoxylate attenuated showed the weight loss percentage, frequency and weight of stool (P<0.01).ARTEMISIA AUCHERI 200 also decreased water content of stool (P<0.05), compare with control group.Conclusions: Extract of ARTEMISIA AUCHERI plant has the same effects as Diphenoxylate has on attenuating castor oil - induced DIARRHEA symptoms and it also reduce fecal water content. With further research, it might be used as a new drug for curing diarrohea.

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APA: Copy

HAKIMIZADEH, E., ASKARY, A., SHAMSIZADEH, A., RAHMANI, M.R., VAZIRINEJAD, R., AYOOBI, F., AMIN, F., REZAZADEH, H.A., KAMALI, B., & ALLAHTAVAKOLI, M.. (2013). EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF ARTEMISIA AUCHERI ON CASTOR OILINDUCED DIARRHEA IN MALE RAT. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 15(3), 1-8. SID. https://sid.ir/paper/58401/en

Vancouver: Copy

HAKIMIZADEH E., ASKARY A., SHAMSIZADEH A., RAHMANI M.R., VAZIRINEJAD R., AYOOBI F., AMIN F., REZAZADEH H.A., KAMALI B., ALLAHTAVAKOLI M.. EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF ARTEMISIA AUCHERI ON CASTOR OILINDUCED DIARRHEA IN MALE RAT. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;15(3):1-8. Available from: https://sid.ir/paper/58401/en

IEEE: Copy

E. HAKIMIZADEH, A. ASKARY, A. SHAMSIZADEH, M.R. RAHMANI, R. VAZIRINEJAD, F. AYOOBI, F. AMIN, H.A. REZAZADEH, B. KAMALI, and M. ALLAHTAVAKOLI, “EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF ARTEMISIA AUCHERI ON CASTOR OILINDUCED DIARRHEA IN MALE RAT,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 3, pp. 1–8, 2013, [Online]. Available: https://sid.ir/paper/58401/en

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