SYNERGISTIC EFFECT OF SILVER NANOPARTICLES WITH STREPTOMYCIN ON THE STREPTOMYCIN-RESISTANT BRUCELLA ABORTUS

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MIRNEJAD R.; ERFANI M.; SADEGHI B.; PIRANFAR V.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2014 | Volume:15 | Issue:5 Page(s): 72-79

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Title

SYNERGISTIC EFFECT OF SILVER NANOPARTICLES WITH STREPTOMYCIN ON THE STREPTOMYCIN-RESISTANT BRUCELLA ABORTUS

Author(s)

MIRNEJAD R. | ERFANI M. | SADEGHI B. | PIRANFAR V. | Issue Writer Certificate

Keywords

BRUCELLA ABORTUSQ3

STREPTOMYCINQ2

SILVER NANOPARTICLESQ1

SYNERGISTIC EFFECTQ2

Abstract

Background and aims: Brucella can be cured hardly and usually encounters with resistance to drug and further recurrence of infection. Side effects of antibiotics that are used to treat are very high. This study aimed to design a method to eliminate drug resistance through using low dose of antibiotics for treatment of brucellosis.Methods: In this experimental study, silver nanorods were synthesized by reduction of silver nitrate and then BRUCELLA ABORTUS was cultured on Hinton Mueller agar. The discs were treated by Kirby-Bauer method with different concentrations of SILVER NANOPARTICLES. SYNERGISTIC EFFECT with STREPTOMYCIN was also done by imbuing the STREPTOMYCIN disk (10μg) with highest concentration of Nano particle that had not inhibitory effect.Results: Investigation the effect of SILVER NANOPARTICLES on STREPTOMYCIN-resistant BRUCELLA ABORTUS showed that dilutions above 25 mM were able to inhibit the BRUCELLA ABORTUS growth.Evaluation of SYNERGISTIC EFFECT of SILVER NANOPARTICLES with STREPTOMYCIN showed that those plates containing STREPTOMYCIN disks with dilution of 12.50 mM caused inhibition zone consistent with CLSI.Conclusion: It seems that SILVER NANOPARTICLES beside antibiotics, destroy bacteria drug-resistant.Using nanoparticles beside common antibiotics may enable us to use very low concentrations of antibiotics and nanoparticles to reduce their adverse effects.

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APA: Copy

MIRNEJAD, R., ERFANI, M., SADEGHI, B., & PIRANFAR, V.. (2014). SYNERGISTIC EFFECT OF SILVER NANOPARTICLES WITH STREPTOMYCIN ON THE STREPTOMYCIN-RESISTANT BRUCELLA ABORTUS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 15(5), 72-79. SID. https://sid.ir/paper/58584/en

Vancouver: Copy

MIRNEJAD R., ERFANI M., SADEGHI B., PIRANFAR V.. SYNERGISTIC EFFECT OF SILVER NANOPARTICLES WITH STREPTOMYCIN ON THE STREPTOMYCIN-RESISTANT BRUCELLA ABORTUS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;15(5):72-79. Available from: https://sid.ir/paper/58584/en

IEEE: Copy

R. MIRNEJAD, M. ERFANI, B. SADEGHI, and V. PIRANFAR, “SYNERGISTIC EFFECT OF SILVER NANOPARTICLES WITH STREPTOMYCIN ON THE STREPTOMYCIN-RESISTANT BRUCELLA ABORTUS,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 5, pp. 72–79, 2014, [Online]. Available: https://sid.ir/paper/58584/en

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