THE EFFECT OF DECREASED ACTIVITY IN THE FORM OF SPINAL CORD LIGATION ON CDK5 EXPRESSION IN SCIATIC NERVE AND BEHAVIORAL TEST OF WISTAR MALE RATS WITH NEUROPATHIC PAIN

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KAZEMI A.; RAHMATI M.; MONTAZER SH.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2016 | Volume:17 | Issue:6 Page(s): 22-32

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Title

THE EFFECT OF DECREASED ACTIVITY IN THE FORM OF SPINAL CORD LIGATION ON CDK5 EXPRESSION IN SCIATIC NERVE AND BEHAVIORAL TEST OF WISTAR MALE RATS WITH NEUROPATHIC PAIN

Author(s)

KAZEMI A. | RAHMATI M. | MONTAZER SH. | Issue Writer Certificate

Keywords

NEUROPATHIC PAINQ2

DECREASED ACTIVITYQ2

CDK5Q2

WISTAR RATSQ2

SCIATIC NERVEQ2

Abstract

Background and aims: NEUROPATHIC PAIN has defined as pain resulting from injury or disease of the somatosensory nervous system. Neurons biochemically are adjusted to reduction and increased in activity, that this Biochemical changes could affect the maintenance and survival of neurons. With regard to regulatory role of CDK5 in the function and structure of the nervous, the aim of this study was to evaluate effect of 6 weeks DECREASED ACTIVITY in the form of spinal cord ligation on CDK5 expression in SCIATIC NERVE of Wistar male rats with NEUROPATHIC PAIN.Methods: 10 adult male WISTAR RATS in the weight range of 267.14±27.36 g were divided into 2 groups including healthy control (C), ligation (SNL). Over the six weeks NEUROPATHIC PAIN behavior tests were conducted continually in groups. In the end change of CDK5 gene expression in SCIATIC NERVE was measured with Real time technique and calculated using the 2-DDCT method.Results: After 6 weeks Soleus muscle weight significantly decreased in ligation group compared to control group (P<0.05). In the behavioral tests of NEUROPATHIC PAIN was shown pain threshold was significantly lower than in ligation group compare to control group (P<0.05). CDK5 gene expression in SCIATIC NERVE increased significantly (pathologically) in ligation group related to control group (P<0.05).Conclusion: It seems that after a period of DECREASED ACTIVITY in the form of spinal cord ligation, pathological Increase of CDK5 gene expression can lead to destructive effect on the neuromuscular system and emerge of pathological markers such as neuromuscular atrophy, acceleration of apoptosis and neurodegenerative destruction.

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APA: Copy

KAZEMI, A., RAHMATI, M., & MONTAZER, SH.. (2016). THE EFFECT OF DECREASED ACTIVITY IN THE FORM OF SPINAL CORD LIGATION ON CDK5 EXPRESSION IN SCIATIC NERVE AND BEHAVIORAL TEST OF WISTAR MALE RATS WITH NEUROPATHIC PAIN. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 17(6), 22-32. SID. https://sid.ir/paper/58674/en

Vancouver: Copy

KAZEMI A., RAHMATI M., MONTAZER SH.. THE EFFECT OF DECREASED ACTIVITY IN THE FORM OF SPINAL CORD LIGATION ON CDK5 EXPRESSION IN SCIATIC NERVE AND BEHAVIORAL TEST OF WISTAR MALE RATS WITH NEUROPATHIC PAIN. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;17(6):22-32. Available from: https://sid.ir/paper/58674/en

IEEE: Copy

A. KAZEMI, M. RAHMATI, and SH. MONTAZER, “THE EFFECT OF DECREASED ACTIVITY IN THE FORM OF SPINAL CORD LIGATION ON CDK5 EXPRESSION IN SCIATIC NERVE AND BEHAVIORAL TEST OF WISTAR MALE RATS WITH NEUROPATHIC PAIN,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 6, pp. 22–32, 2016, [Online]. Available: https://sid.ir/paper/58674/en

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