REDUCTION OF VANCOMYCIN RESISTANT IN VAN A AND VAN B CONTAINING VANCOMYCIN RESISTANT ENTEROCOCCUS (VRE) ISOLATES IN PRESENCE OF LACTOFERRIN PROTEIN

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KHORVASH F.; NIKOOEI M.; MEIDANI M.; SHOKRI D.; ZOLFAGHARI M.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2016 | Volume:17 | Issue:6 Page(s): 45-52

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Title

REDUCTION OF VANCOMYCIN RESISTANT IN VAN A AND VAN B CONTAINING VANCOMYCIN RESISTANT ENTEROCOCCUS (VRE) ISOLATES IN PRESENCE OF LACTOFERRIN PROTEIN

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Keywords

VANCOMYCIN RESISTANT ENTEROCOCCUSQ2

MINIMUM INHIBITORY CONCENTRATIONQ2

LACTOFERRIN PROTEINQ2

VANCOMYCIN RESISTANT GENESQ2

Abstract

Background and aims: The protein Lactoferrin (LF) has the confirmed antimicrobic effects. The aim of this research was to investigate the effect of LF on the MINIMUM INHIBITORY CONCENTRATION (MIC) of vancomycin for van A and van B resistant isolates of enterococcus.Methods: In this cross sectional study, after isolating and identifying 265 strains of enterococci from clinical specimens, The MIC test by using E-test method was performed for the vancomycin resistance enterococci specimens with the vancomycin and teicoplanin antibiotics. To study the presence of van A and van B genes in VANCOMYCIN RESISTANT ENTEROCOCCUS was used Real time PCR method. Then, the effect of Lactoferrin on the MIC of VRE isolates was assessed and analyzed using SPSS software and linear regression and Pearson correlation test with significance level P<0.05.Results: Van A isolate at (2048 mg/ml) concentration of LF showed 85 and 80 fold reduced the MIC of vancomycin in modified E-test and Microtiter methods respectively and in van B isolate at the concentration of (512 mg/ml) of LF 10 and 10.3 fold reduced the MIC of vancomycin in modified E-test and broth Microtiter methods, respectively. Lactoferrin index showed a significant positive correlation with reduced vancomycin MIC (P<0.001 and r= 0.183).Conclusion: Different concentrations of LACTOFERRIN PROTEIN induced reduction in VRE isolates contained van A and van B genes in vivo concentrations suggest a potential use for this protein as an adjunctive agent to vancomycin.

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APA: Copy

KHORVASH, F., NIKOOEI, M., MEIDANI, M., SHOKRI, D., & ZOLFAGHARI, M.. (2016). REDUCTION OF VANCOMYCIN RESISTANT IN VAN A AND VAN B CONTAINING VANCOMYCIN RESISTANT ENTEROCOCCUS (VRE) ISOLATES IN PRESENCE OF LACTOFERRIN PROTEIN. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 17(6), 45-52. SID. https://sid.ir/paper/58678/en

Vancouver: Copy

KHORVASH F., NIKOOEI M., MEIDANI M., SHOKRI D., ZOLFAGHARI M.. REDUCTION OF VANCOMYCIN RESISTANT IN VAN A AND VAN B CONTAINING VANCOMYCIN RESISTANT ENTEROCOCCUS (VRE) ISOLATES IN PRESENCE OF LACTOFERRIN PROTEIN. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;17(6):45-52. Available from: https://sid.ir/paper/58678/en

IEEE: Copy

F. KHORVASH, M. NIKOOEI, M. MEIDANI, D. SHOKRI, and M. ZOLFAGHARI, “REDUCTION OF VANCOMYCIN RESISTANT IN VAN A AND VAN B CONTAINING VANCOMYCIN RESISTANT ENTEROCOCCUS (VRE) ISOLATES IN PRESENCE OF LACTOFERRIN PROTEIN,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 6, pp. 45–52, 2016, [Online]. Available: https://sid.ir/paper/58678/en

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