EFFECT OF SECRETORY FACTORS OF MESENCHYMAL STEM CELL PULSED WITH NICOTINE ON THE NEUTROPHILS FUNCTIONS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

POURTAYEB S.; ABTAHI FROUSHANI S.M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahrekord University of Medical Sciences Year:2016 | Volume:18 | Issue:4 Page(s): 94-105

Download Full-Text

Persian Verion

View:

716

Download:

Cites:

Information Journal Paper

Title

EFFECT OF SECRETORY FACTORS OF MESENCHYMAL STEM CELL PULSED WITH NICOTINE ON THE NEUTROPHILS FUNCTIONS

Author(s)

POURTAYEB S. | ABTAHI FROUSHANI S.M. | Issue Writer Certificate

Keywords

MESENCHYMAL STEM CELLQ2

NEUTROPHILQ2

NICOTINEQ3

Abstract

Background and aims: The effects of the MESENCHYMAL STEM CELLs (MSCs) on the NEUTROPHIL functions has been revealed in recent documents. Moreover, it has been showed that MESENCHYMAL STEM CELLs (MSCs) express some of the nicotinic receptor subunits. The aim of the present study was to determine the effects of the secretory factors from MESENCHYMAL STEM CELL pulsed with NICOTINE on the NEUTROPHIL functions.Methods: After isolation of MESENCHYMAL STEM CELLs from bone marrow of rats, these cells pulsed with different concentration of NICOTINE (0, 0.1, 0.5 and 1 mM) for 48h. Then, NEUTROPHILs were co-cultured with MSCs supernatants for 4 h and the functions of NEUTROPHILs were evaluated.Results: The results showed that MSCs supernatants pulsed with NICOTINE could significantly enhance the viability and phagocytic activity of NEUTROPHILs more profound that MSCs supernatants without treatment. Furthermore, supernatants of MSCs treated with NICOTINE significantly reduced the respiratory burst and nitric oxide production of NEUTROPHILs more prominent than and /or supernatants of the MSCs without treatment.Conclusion: Collectively, these findings may offer new insight into the potential mechanisms underlying the immunomodulatory and anti-inflammatory effects of NICOTINE.

Cites

No record.

References

Cite

APA: Copy

POURTAYEB, S., & ABTAHI FROUSHANI, S.M.. (2016). EFFECT OF SECRETORY FACTORS OF MESENCHYMAL STEM CELL PULSED WITH NICOTINE ON THE NEUTROPHILS FUNCTIONS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 18(4), 94-105. SID. https://sid.ir/paper/58883/en

Vancouver: Copy

POURTAYEB S., ABTAHI FROUSHANI S.M.. EFFECT OF SECRETORY FACTORS OF MESENCHYMAL STEM CELL PULSED WITH NICOTINE ON THE NEUTROPHILS FUNCTIONS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;18(4):94-105. Available from: https://sid.ir/paper/58883/en

IEEE: Copy

S. POURTAYEB, and S.M. ABTAHI FROUSHANI, “EFFECT OF SECRETORY FACTORS OF MESENCHYMAL STEM CELL PULSED WITH NICOTINE ON THE NEUTROPHILS FUNCTIONS,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 18, no. 4, pp. 94–105, 2016, [Online]. Available: https://sid.ir/paper/58883/en

Related Journal Papers