EFFECT OF ANDROGRAPHOLIDE EXTRACT ON BLOOD GLUCOSE AND LIPID PROFILE IN RATS WITH SECONDARY IRON OVERLOAD

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MEHRI PIRAYVATLO A.; ALIPANAH MOGHADAM R.; MAZANI M.; MANAFI F.; MALEKZADEH V.; NEMATI A.; NAGHIZADEH BAGHI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Ardabil University of Medical Sciences Year:2017 | Volume:16 | Issue:4 Page(s): 399-408

Download Full-Text

Persian Verion

View:

575

Download:

Cites:

Information Journal Paper

Title

EFFECT OF ANDROGRAPHOLIDE EXTRACT ON BLOOD GLUCOSE AND LIPID PROFILE IN RATS WITH SECONDARY IRON OVERLOAD

Author(s)

Keywords

IRON OVERLOADQ1

ANDROGRAPHOLIDEQ1

GLUCOSEQ2

LIPID PROFILESQ1

RATQ2

Abstract

Background & objectives: IRON OVERLOAD is involved in the pathophysiology of many diseases including diabetes. In fact, the excess iron by creating free radicals makes damage to pancreas and leads to insulin resistance and diabetes. ANDROGRAPHOLIDE extract has hypoglycemic and antioxidant properties. This study has surveyed the effects of ANDROGRAPHOLIDE on blood GLUCOSE and lipid profile in RATs with secondary IRON OVERLOAD.Methods: In this experimental study, 36 male Wistar RATs were randomly divided into 6 groups: the healthy control group, secondary IRON OVERLOAD group, secondary IRON OVERLOAD groups treated with a dose of 3.5 and 7 mg/kg of ANDROGRAPHOLIDE extract, and ANDROGRAPHOLIDE groups treated with a dose of 3.5 and 7 mg/kg of extract. Iron and extract were injected for 6 and 12 days, respectively. Blood samples were taken for measurement of blood GLUCOSE and LIPID PROFILES. Data were analyzed using ANOVA test.Results: The pathological results of samples from liver of animals receiving iron showed that the iron was deposited in the liver tissues. Iron injection significantly increased blood GLUCOSE levels compared to healthy control group (p<0.05). In the IRON OVERLOAD group, ANDROGRAPHOLIDE extract with a dose of 3.5 mg/kg or 7 mg/kg significantly decreased blood GLUCOSE levels (p<0.05). Iron injections did not increase the serum triglyceride and cholesterollevels. Injections of and rographolide extract with a dose of 3.5 mg/kg and 7 mg/kg, significantly decreased the cholesterol levels compared to iron receiving group (p<0.05).Conclusion: Results of this study showed that the ANDROGRAPHOLIDE with different doses may be effective in the treatment of diabetes by reducing serum GLUCOSE and cholesterol levels.

Cites

No record.

References

IRON DEXTRAN INCREASES HEPATIC OXIDATIVE STRESS AND ALTERS EXPRESSION OF GENES RELATED TO LIPID METABOLISM CONTRIBUTING TO HYPERLIPIDAEMIA IN MURINE MODEL

Cite

APA: Copy

MEHRI PIRAYVATLO, A., ALIPANAH MOGHADAM, R., MAZANI, M., MANAFI, F., MALEKZADEH, V., NEMATI, A., & NAGHIZADEH BAGHI, A.. (2017). EFFECT OF ANDROGRAPHOLIDE EXTRACT ON BLOOD GLUCOSE AND LIPID PROFILE IN RATS WITH SECONDARY IRON OVERLOAD. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 16(4), 399-408. SID. https://sid.ir/paper/59645/en

Vancouver: Copy

MEHRI PIRAYVATLO A., ALIPANAH MOGHADAM R., MAZANI M., MANAFI F., MALEKZADEH V., NEMATI A., NAGHIZADEH BAGHI A.. EFFECT OF ANDROGRAPHOLIDE EXTRACT ON BLOOD GLUCOSE AND LIPID PROFILE IN RATS WITH SECONDARY IRON OVERLOAD. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2017;16(4):399-408. Available from: https://sid.ir/paper/59645/en

IEEE: Copy

A. MEHRI PIRAYVATLO, R. ALIPANAH MOGHADAM, M. MAZANI, F. MANAFI, V. MALEKZADEH, A. NEMATI, and A. NAGHIZADEH BAGHI, “EFFECT OF ANDROGRAPHOLIDE EXTRACT ON BLOOD GLUCOSE AND LIPID PROFILE IN RATS WITH SECONDARY IRON OVERLOAD,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 16, no. 4, pp. 399–408, 2017, [Online]. Available: https://sid.ir/paper/59645/en

Related Journal Papers