COMPARISON BETWEEN THE PROTECTIVE EFFECTS OF ETOMOXIR AND RANOLAZINE ON INFARCT SIZE IN THE ISOLATED ISCHEMIC RAT HEART

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NAJAFI MOSLEM; ETERAF OSKOUEI T.; GARJANI A.R.

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Journal: JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS) Year:2008 | Volume:8 | Issue:1 (27) Page(s): 89-94

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Title

COMPARISON BETWEEN THE PROTECTIVE EFFECTS OF ETOMOXIR AND RANOLAZINE ON INFARCT SIZE IN THE ISOLATED ISCHEMIC RAT HEART

Author(s)

NAJAFI MOSLEM | ETERAF OSKOUEI T. | GARJANI A.R. | Issue Writer Certificate

Keywords

ETOMOXIRQ3

RANOLAZINEQ3

INFARCT SIZEQ3

RAT ISOLATED HEARTQ3

Abstract

Background & Objective: Some studies have shown the protective effects of ETOMOXIR and RANOLAZINE in the hypoxic and ischemic condition of the heart. However, at present, there has not been any comparative study between the effects of ETOMOXIR and RANOLAZINE on ischemia/reperfusion injuries (esp. INFARCT SIZE), So their effects on INFARCT SIZE in the ischemic isolated rat heart were studied and compared.Methods: Isolated rat hearts were divided into 3 groups randomly (n=6 in each group) and mounted on a Langendorff apparatus then per fused by a modified Krebs-Henseleitsolution. In control group, the hearts were perfused by the solution at stabilization, 30min regional ischemia and l20min reperfusion while in the test groups they were perfuse by enriched Krebs solution with 1mM of ETOMOXIR or 20 mM of RANOLAZINE during ischemia/reperfusion. At the end of reperfusion, Evans Blue solution was infused to stain the non-ischemic area. Then the heart was incubated in 1%thriphenyl tetrazolium chloride solution and fixed by formalin. The INFARCT SIZE was determined by a computerized planimetry package.Results: The results showed that ETOMOXIR results in the significant decrease in the size of infracted area. In the control group, INFARCT SIZE was 46.3±2.9% while ETOMOXIR reduced INFARCT SIZE to 20.9±5% (p<0.01). Perfusion of the hearts by RANOLAZINE enriched Krebs solution produced greater reduction in INFARCT SIZE (16.4±3.6%p,<0.001).The effect was not statistically significant between the test groups.Conclusion: It seems that ETOMOXIR (an inhibitor of fatty acid uptake by mitochondria) and RANOLAZINE (an inhibitor of fatty acid oxidation by mitochondria) probably, by indirect increasing of glucose oxidation, duning ischemia and reperfusion, may improve reperfusion recovery of ischemic heart and reduce INFARCT SIZE. The results showed protective effects of ETOMOXIR and RANOLAZINE on INFARCT SIZE without any significant difference between them.

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APA: Copy

NAJAFI, MOSLEM, ETERAF OSKOUEI, T., & GARJANI, A.R.. (2008). COMPARISON BETWEEN THE PROTECTIVE EFFECTS OF ETOMOXIR AND RANOLAZINE ON INFARCT SIZE IN THE ISOLATED ISCHEMIC RAT HEART. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 8(1 (27)), 89-94. SID. https://sid.ir/paper/59867/en

Vancouver: Copy

NAJAFI MOSLEM, ETERAF OSKOUEI T., GARJANI A.R.. COMPARISON BETWEEN THE PROTECTIVE EFFECTS OF ETOMOXIR AND RANOLAZINE ON INFARCT SIZE IN THE ISOLATED ISCHEMIC RAT HEART. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2008;8(1 (27)):89-94. Available from: https://sid.ir/paper/59867/en

IEEE: Copy

MOSLEM NAJAFI, T. ETERAF OSKOUEI, and A.R. GARJANI, “COMPARISON BETWEEN THE PROTECTIVE EFFECTS OF ETOMOXIR AND RANOLAZINE ON INFARCT SIZE IN THE ISOLATED ISCHEMIC RAT HEART,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 8, no. 1 (27), pp. 89–94, 2008, [Online]. Available: https://sid.ir/paper/59867/en

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