PROTECTIVE ROLE OF PHARMACOLOGIC POSTCONDITIONING WITH NATURAL HONEY ON MYOCARDIAL INFARCTION SIZE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NAJAFI MOSLEM; GHARAKHANI A.; GHAVIMI H.; ETERAF OSKOUEI T.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2011 | Volume:13 | Issue:2 (59) Page(s): 12-18

Download Full-Text

Persian Verion

View:

1,040

Download:

Cites:

Information Journal Paper

Title

PROTECTIVE ROLE OF PHARMACOLOGIC POSTCONDITIONING WITH NATURAL HONEY ON MYOCARDIAL INFARCTION SIZE

Author(s)

NAJAFI MOSLEM | GHARAKHANI A. | GHAVIMI H. | ETERAF OSKOUEI T. | Issue Writer Certificate

Keywords

HONEYQ2

POSTCONDITIONINGQ3

INFARCTION SIZEQ3

ISOLATED HEARTQ3

Abstract

BACKGROUND AND OBJECTIVE: HONEY has been noticed as an effective drug more than a nutrient. There is no report regarding cardioprotective effects of POSTCONDITIONING with natural HONEY. In the present study, effects of POSTCONDITIONING by HONEY on myocardial INFARCTION SIZE in ischemic-reperfused isolated rat heart were investigated.METHODS: this experimental study was performed on 42 male Wistar rats weighing 270-330 g. The rats' hearts were isolated and divided into five groups including a control and four POSTCONDITIONING groups (n= 8-10 in each). The hearts were subjected to 30 min regional ischemia followed by 120 min reperfusion. In the control group, the hearts were perfused by normal Krebs-Henseleit (K/H) solution throughout the experiment, however in the POSTCONDITIONING groups, they were perfused with HONEY (0.25, 0.5 and 1%) enriched K/H solution or glucose (equivalent concentration in 1% HONEY solution) from 10 min before to 10 min after reperfusion. To determine the infarct size, the hearts were perfused with Evans blue dye then cut into slices and incubated with triphenyltetrazolium chloride. Finally, the infarct size was determined by computerized planimetry.FINDINGS: Perfusion of ISOLATED HEARTs with HONEY as a POSTCONDITIONING agent significantly decreased infarct size and infarcted volume in the all treated groups. In the control group, the infarct size was 47±3%, however, natural HONEY (0.25, 0.5 and 1%) and glucose reduced it to 26±3, 6±3, 5±2 and 21±2%, respectively (p<0.001 for all groups).CONCLUSION: The results showed protective effects of POSTCONDITIONING by natural HONEY against ischemia-reperfusion injuries as reduction of INFARCTION SIZE. Probably, antioxidant activity of HONEY, scavenging of free radicals and the presence of energy sources in HONEY composition may involve in these protective effects.

Cites

No record.

References

No record.

Cite

APA: Copy

NAJAFI, MOSLEM, GHARAKHANI, A., GHAVIMI, H., & ETERAF OSKOUEI, T.. (2011). PROTECTIVE ROLE OF PHARMACOLOGIC POSTCONDITIONING WITH NATURAL HONEY ON MYOCARDIAL INFARCTION SIZE. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 13(2 (59)), 12-18. SID. https://sid.ir/paper/72927/en

Vancouver: Copy

NAJAFI MOSLEM, GHARAKHANI A., GHAVIMI H., ETERAF OSKOUEI T.. PROTECTIVE ROLE OF PHARMACOLOGIC POSTCONDITIONING WITH NATURAL HONEY ON MYOCARDIAL INFARCTION SIZE. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2011;13(2 (59)):12-18. Available from: https://sid.ir/paper/72927/en

IEEE: Copy

MOSLEM NAJAFI, A. GHARAKHANI, H. GHAVIMI, and T. ETERAF OSKOUEI, “PROTECTIVE ROLE OF PHARMACOLOGIC POSTCONDITIONING WITH NATURAL HONEY ON MYOCARDIAL INFARCTION SIZE,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 13, no. 2 (59), pp. 12–18, 2011, [Online]. Available: https://sid.ir/paper/72927/en

Related Journal Papers