STUDY THE EFFECT OF L-CARNITINE ON INFARCT SIZE IN THE ISCHEMIC–REPERFUSED ISOLATED RAT HEARTS

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NAJAFI M.; GARJANI A.

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Journal: PHARMACEUTICAL SCIENCES Year:2005 | Volume:- | Issue:1 Page(s): 47-52

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Title

STUDY THE EFFECT OF L-CARNITINE ON INFARCT SIZE IN THE ISCHEMIC–REPERFUSED ISOLATED RAT HEARTS

Author(s)

NAJAFI M. | GARJANI A. | Issue Writer Certificate

Keywords

L-CARNITINEQ2

INFARCT SIZEQ2

ISOLATED HEARTQ2

RATQ2

Abstract

Carnitine is a vital biologic substance for transporting fatty acids into myocytes and facilitates fatty acids β-oxidation for energy production. There are some conflicting findings about its cardioprotective effects such as decreasing the INFARCT SIZE during ischemia / reperfusion. In this study, the effects of L-CARNITINE on INFARCT SIZE in the ischemic isolated RAT hearts were investigated. Male Sprague-Dawley RATs (270-330g) were divided into 5 groups randomly and they were anesthetized by sodium pentobarbital (50-60 mg/kg-ip).Heart was removed and quickly mounted on a Langendorff apparatus and perfused by a modified Krebs -Henseleit solution under constant pressure at 37 C º. In control group (n=6), the hearts were perfused only by normal Krebs -Henseleit solution at stabilization, 30 min regional ischemia and120 min reperfusion, while in the test groups (1-4 groups , n=6 in each group), during ischemia / reperfusion , the hearts were perfused with 0.5,2.5,3.75 and 5mM of L-CARNITINE - enriched Krebs -Henseleit solution , respectively. At the end of reperfusion, 1% Evans Blue solution was infused to stain the non-ischemic area. Then the heart was cut into slices and incubated by 1% Triphenyltetrazolium chloride (TTZ) solution and fixed by formalin. The area of infracted tissue and area at risk were determined by computerized planimetry. In control group, the INFARCT SIZE was 46.29 ±3.46%, while in the test groups, the addition of L-CARNITINE (0.5, 2.5, 3.75 and 5mM) into the Krebs solution during ischemia and reperfusion, reduced INFARCT SIZE to 27 ± 2.85, 25.53 ± 5.40, 19.53 ± 4.88 and15.68 ± 2.78 %, respectively (p<0.001).The effect was dose-dependent at the doses of 0.5 – 5mM.There was no significant difference between and within test groups using ANOVA oneway test. Considering these results, we conclude that L-CARNITINE has a protective effect against cardiac ischemic reperfusion injuries and reduces the INFARCT SIZE.

Cites

STUDY OF ISCHEMIC AND PHARMACOLOGIC POSTCONDITIONING ON INFARCT SIZE IN THE ISCHEMIC REPERFUSED ISOLATED HEART

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APA: Copy

NAJAFI, M., & GARJANI, A.. (2005). STUDY THE EFFECT OF L-CARNITINE ON INFARCT SIZE IN THE ISCHEMIC–REPERFUSED ISOLATED RAT HEARTS. PHARMACEUTICAL SCIENCES, -(1), 47-52. SID. https://sid.ir/paper/48430/en

Vancouver: Copy

NAJAFI M., GARJANI A.. STUDY THE EFFECT OF L-CARNITINE ON INFARCT SIZE IN THE ISCHEMIC–REPERFUSED ISOLATED RAT HEARTS. PHARMACEUTICAL SCIENCES[Internet]. 2005;-(1):47-52. Available from: https://sid.ir/paper/48430/en

IEEE: Copy

M. NAJAFI, and A. GARJANI, “STUDY THE EFFECT OF L-CARNITINE ON INFARCT SIZE IN THE ISCHEMIC–REPERFUSED ISOLATED RAT HEARTS,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 47–52, 2005, [Online]. Available: https://sid.ir/paper/48430/en

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