IMMUNOPHENOTYPING ANALYSIS OF TUMOR INFILTRATING T LYMPHOCYTES IN PATIENTS WITH BREAST CANCER

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AMANI D.; MOHAMMAD HASAN ZOHEYR; KARIMZADEH MOJTABA; FEYZ ELAHZADEH S.; DEHGHAN MOHAMMAD HOSSEIN

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Journal: JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS) Year:2007 | Volume:7 | Issue:4 (26) Page(s): 344-352

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Title

IMMUNOPHENOTYPING ANALYSIS OF TUMOR INFILTRATING T LYMPHOCYTES IN PATIENTS WITH BREAST CANCER

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Keywords

BREAST CANCERQ2

TUMOR INFILTRATING LYMPHOCYTESQ3

T CELLSQ3

Abstract

Background & Objective: Tumor-infiltrating lymphocytes (TILs) develop as recognition and defense against malignant cells by the host immune system. T CELLS are the most tumor infiltrating immune cells. There are controversial data about intratumor T CELLS and many have proposed diverse mechanisms for dysfunction of TILs. The aim of this study is analyzing Tumor Infiltrating T lymphocytes in patients with BREAST CANCER by immunophenotyping.Methods: Sixteen women suffering from BREAST CANCER were examined; thirteen of them were confirmed histologically to be invasive ductal carcinoma (IDC). Tissue samples from patients and matched control group were processed for analysis by flow cytometry.Results: Results indicated that human BREAST CANCER contain variable numbers of TILs. No significant changes in the percent of intratumor CD45+, CD3+ and CD3+ / CD45+ cells were observed between studied groups. Also there were no significant differences between cancer patients (group 1 and 2) and control group in the case of infiltration and activation status of T CELLS subpopulations. CD4+ cells in IDC patients and CD8+ cells in patients with other tumors (ILC+AMC) were the most infiltrated TILs. Intratumor TCD8+ cells expressed HLA-DR markers significantly more than CD25 as activation marker. In this investigation we could not find any correlation between TIL and both size and clinical stages of tumor.Conclusion: An immune infiltrate is an invariable finding in BREAST CANCERs, with considering the activation marker expression, TIL may be activated, albeit partially. Understanding the insensitive and/or suppressive nature of cancer cells to the immune system may provide important insights into tumor escape mechanisms as well as the development of anti-cancer strategies.

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APA: Copy

AMANI, D., MOHAMMAD HASAN, ZOHEYR, KARIMZADEH, MOJTABA, FEYZ ELAHZADEH, S., & DEHGHAN, MOHAMMAD HOSSEIN. (2007). IMMUNOPHENOTYPING ANALYSIS OF TUMOR INFILTRATING T LYMPHOCYTES IN PATIENTS WITH BREAST CANCER. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 7(4 (26)), 344-352. SID. https://sid.ir/paper/59901/en

Vancouver: Copy

AMANI D., MOHAMMAD HASAN ZOHEYR, KARIMZADEH MOJTABA, FEYZ ELAHZADEH S., DEHGHAN MOHAMMAD HOSSEIN. IMMUNOPHENOTYPING ANALYSIS OF TUMOR INFILTRATING T LYMPHOCYTES IN PATIENTS WITH BREAST CANCER. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2007;7(4 (26)):344-352. Available from: https://sid.ir/paper/59901/en

IEEE: Copy

D. AMANI, ZOHEYR MOHAMMAD HASAN, MOJTABA KARIMZADEH, S. FEYZ ELAHZADEH, and MOHAMMAD HOSSEIN DEHGHAN, “IMMUNOPHENOTYPING ANALYSIS OF TUMOR INFILTRATING T LYMPHOCYTES IN PATIENTS WITH BREAST CANCER,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 7, no. 4 (26), pp. 344–352, 2007, [Online]. Available: https://sid.ir/paper/59901/en

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