EFFECT OF HYDROALCOHOLIC EXTRACTS OF TRUFFLE (TERFEZIA BOUDIERI) PREMEDICATION ON IMPROVING HEPATIC FACTORS IN CCL4-INDUCED LIVER INJURY IN MALE RATS

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MAHMOUDZADE Y.; MOTAVALIBASHI S.E.; BAMDAD KH.; ZABIHI E.; SHEIKHKANLOUI MILAN H.; HAMIDI N.

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Journal: Journal of Ardabil University of Medical Sciences Year:2017 | Volume:17 | Issue:1 Page(s): 58-68

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Title

EFFECT OF HYDROALCOHOLIC EXTRACTS OF TRUFFLE (TERFEZIA BOUDIERI) PREMEDICATION ON IMPROVING HEPATIC FACTORS IN CCL4-INDUCED LIVER INJURY IN MALE RATS

Author(s)

Keywords

TERFEZIA BOUDIERIQ1

CARBON TETRACHLORIDEQ2

ANTIOXIDANTSQ2

LIVER INJURYQ1

RATQ2

Abstract

Background & objectives: TERFEZIA BOUDIERI (TB) has more than 15 types of proteins, gallic acid, catechins, flavonoids, tannins and other compounds such as beta-carotene and linoleic acid. Some of these compounds have antioxidant and anti-hyperlipidemia effects. Therefore, this study aimed to examine the antioxidant and protective effects of this fungus on the LIVER INJURY induced by CARBON TETRACHLORIDE.Methods: 30 male Wistar RATs were divided randomly into 5 groups (each group containing 6).Group 1 (normal control group) and group 2 (control CCl4) were given normal saline for 14 days. Group 3, 4 and 5 received 500, 1000 and 1500 mg/ kg doses of methanol extract of TB for 14 days, respectively before the injection of CARBON TETRACHLORIDE. In the fourteenth day, all groups except group 1 were given 1.5 ml/kg of CARBON TETRACHLORIDE (V / V 1: 1 dissolved in olive oil). Group 1, instead of CARBON TETRACHLORIDE, received 1.5 ml/kg of olive oil on the fourteenth day.Results: Injection of CARBON TETRACHLORIDE in RATs increased serum activity of ALT, AST, ALP and serum degrees of triglycerides, VLDL, LDL, HDL, total cholesterol, glucose, and reduced HDL and total antioxidant capacity (TAC); while pre-treatment with methanol extract of TB significantly reversed the changes.Conclusion: The results of this study showed that methanol extract of TB can protect the liver against oxidants and free radicals produced by CARBON TETRACHLORIDE metabolism.

Cites

THE EFFECT OF HYDROALCOHOLIC EXTRACT OF TERFEZIA BOUDIERI ON SPERM PARAMETERS AND TESTOSTERONE LEVELS IN RATS

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APA: Copy

MAHMOUDZADE, Y., MOTAVALIBASHI, S.E., BAMDAD, KH., ZABIHI, E., SHEIKHKANLOUI MILAN, H., & HAMIDI, N.. (2017). EFFECT OF HYDROALCOHOLIC EXTRACTS OF TRUFFLE (TERFEZIA BOUDIERI) PREMEDICATION ON IMPROVING HEPATIC FACTORS IN CCL4-INDUCED LIVER INJURY IN MALE RATS. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 17(1), 58-68. SID. https://sid.ir/paper/59924/en

Vancouver: Copy

MAHMOUDZADE Y., MOTAVALIBASHI S.E., BAMDAD KH., ZABIHI E., SHEIKHKANLOUI MILAN H., HAMIDI N.. EFFECT OF HYDROALCOHOLIC EXTRACTS OF TRUFFLE (TERFEZIA BOUDIERI) PREMEDICATION ON IMPROVING HEPATIC FACTORS IN CCL4-INDUCED LIVER INJURY IN MALE RATS. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2017;17(1):58-68. Available from: https://sid.ir/paper/59924/en

IEEE: Copy

Y. MAHMOUDZADE, S.E. MOTAVALIBASHI, KH. BAMDAD, E. ZABIHI, H. SHEIKHKANLOUI MILAN, and N. HAMIDI, “EFFECT OF HYDROALCOHOLIC EXTRACTS OF TRUFFLE (TERFEZIA BOUDIERI) PREMEDICATION ON IMPROVING HEPATIC FACTORS IN CCL4-INDUCED LIVER INJURY IN MALE RATS,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 17, no. 1, pp. 58–68, 2017, [Online]. Available: https://sid.ir/paper/59924/en

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