CYTOGENETIC STUDY OF 100 COUPLES WITH REPRODUCTIVE FAILURE BY GTG-BANDING METHOD IN THE NORTHWEST OF IRAN

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ALIZADEH HAJIKHAJEHLU R.; RAHMANI S.A.

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Journal: Journal of Ardabil University of Medical Sciences Year:2017 | Volume:17 | Issue:1 Page(s): 113-121

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Title

CYTOGENETIC STUDY OF 100 COUPLES WITH REPRODUCTIVE FAILURE BY GTG-BANDING METHOD IN THE NORTHWEST OF IRAN

Author(s)

ALIZADEH HAJIKHAJEHLU R. | RAHMANI S.A. | Issue Writer Certificate

Keywords

CHROMOSOMAL ABNORMALITIESQ2

RECURRENT SPONTANEOUS ABORTIONQ2

STILLBIRTHQ3

Abstract

Background & Objectives: Infertility (abortion & STILLBIRTH) is one of the most common medical problems during pregnancy. Approximately 10-15% of all clinically recognized pregnancies are lost before the birth. Pregnancy loss is a multifactorial phenomenon. This study was an attempt to analysis the cytogenetic abnormalities of the parents with frequent spontaneous abortion and STILLBIRTH.Methods: In this study, the samples were analyzed by GTG-banding technique.Results: From a total of 200 reviewed blood samples, 188 persons (94%) had natural karyotype and 12 persons (6%) had CHROMOSOMAL ABNORMALITIES. Chromosomal aberrations were found in 5 (2.5%) females and 7 (3.5%) males. The prevalence of CHROMOSOMAL ABNORMALITIES was as follows: 5 (41.6%) pericentric inversion of chromosome 9, 3 (25%) polymorphism 15p+, 1 (8.3%) translocation, 1 (8.3%) polymorphism 15ps+, 1 (8.3%) polymorphism 1qh+and 1 (8.3%) unknown chromophil band on the short arm of chromosome 21.Conclusion: Chromosomal analysis is an important etiological investigation in couples with RECURRENT SPONTANEOUS ABORTIONs and STILLBIRTH, and genetic counseling helps to make a correct decision on further options of reproduction.

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APA: Copy

ALIZADEH HAJIKHAJEHLU, R., & RAHMANI, S.A.. (2017). CYTOGENETIC STUDY OF 100 COUPLES WITH REPRODUCTIVE FAILURE BY GTG-BANDING METHOD IN THE NORTHWEST OF IRAN. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 17(1), 113-121. SID. https://sid.ir/paper/59931/en

Vancouver: Copy

ALIZADEH HAJIKHAJEHLU R., RAHMANI S.A.. CYTOGENETIC STUDY OF 100 COUPLES WITH REPRODUCTIVE FAILURE BY GTG-BANDING METHOD IN THE NORTHWEST OF IRAN. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2017;17(1):113-121. Available from: https://sid.ir/paper/59931/en

IEEE: Copy

R. ALIZADEH HAJIKHAJEHLU, and S.A. RAHMANI, “CYTOGENETIC STUDY OF 100 COUPLES WITH REPRODUCTIVE FAILURE BY GTG-BANDING METHOD IN THE NORTHWEST OF IRAN,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 17, no. 1, pp. 113–121, 2017, [Online]. Available: https://sid.ir/paper/59931/en

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