NUMERICAL AND STRUCTURAL CHROMOSOME ABERRATIONS IN ABORTED FETUSES WITH USING FETAL CELL CULTURE AND STAINING WITH GTG BANDING METHOD

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TABATABAEI SEYEH MAHMOUD; BAGHINIA M.R.; BEYRAMI M.; MALEKIRAD A.A.

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Paper Information

Journal: Journal of Arak University Medical Sciences Year:2009 | Volume:12 | Issue:3 (48) Page(s): 92-100

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Title

NUMERICAL AND STRUCTURAL CHROMOSOME ABERRATIONS IN ABORTED FETUSES WITH USING FETAL CELL CULTURE AND STAINING WITH GTG BANDING METHOD

Author(s)

TABATABAEI SEYEH MAHMOUD | BAGHINIA M.R. | BEYRAMI M. | MALEKIRAD A.A. | Issue Writer Certificate

Keywords

RECURRENT ABORTIONQ2

CHROMOSOME ABERRATIONSQ3

GTG BANDINGQ3

Abstract

Background: Approximately 15-20% of pregnancies terminate to abortion. More than 50% of spontaneous abortions in 8-15 weeks pregnant mothers are related to genetically abnormalities. So, approximately 95% of them are related to numerical and 5% structural CHROMOSOME ABERRATIONS. Until now, neither of known human chromosomal abnormalities are treatable, and only way against these diseases limit to prenatal diagnosis and abortion of affected fetuses. The purpose of this study was determined the CHROMOSOME ABERRATIONS with cytogenetically methods.Materials and Methods: In this cross-sectional analytic study, 56 aborted fetuses were studied to detection of abnormalities frequency. Amnion-chorine culture, placenta, fetal tissue and aborted products from metaphase cells for gathering metaphase cells were used.Results: After cell culture, chromosome typing and GTG-banding Technique, trisomy 21 with highest frequency (12.5%) and isochromosomy 21, X and monosomy X with lowest frequency (1.8% for each them) was resulted.Conclusion: Not only chromosomal aberrations have important role in recurrent miscarriages, but also frequency rates of chromosomal aberrations in our country are similarity with other countries.Also cytogenetically diagnostic methods such as GTG-banding are a powerful and reliable technique for investigation of parents with RECURRENT ABORTION.

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APA: Copy

TABATABAEI, SEYEH MAHMOUD, BAGHINIA, M.R., BEYRAMI, M., & MALEKIRAD, A.A.. (2009). NUMERICAL AND STRUCTURAL CHROMOSOME ABERRATIONS IN ABORTED FETUSES WITH USING FETAL CELL CULTURE AND STAINING WITH GTG BANDING METHOD. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 12(3 (48)), 92-100. SID. https://sid.ir/paper/69395/en

Vancouver: Copy

TABATABAEI SEYEH MAHMOUD, BAGHINIA M.R., BEYRAMI M., MALEKIRAD A.A.. NUMERICAL AND STRUCTURAL CHROMOSOME ABERRATIONS IN ABORTED FETUSES WITH USING FETAL CELL CULTURE AND STAINING WITH GTG BANDING METHOD. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2009;12(3 (48)):92-100. Available from: https://sid.ir/paper/69395/en

IEEE: Copy

SEYEH MAHMOUD TABATABAEI, M.R. BAGHINIA, M. BEYRAMI, and A.A. MALEKIRAD, “NUMERICAL AND STRUCTURAL CHROMOSOME ABERRATIONS IN ABORTED FETUSES WITH USING FETAL CELL CULTURE AND STAINING WITH GTG BANDING METHOD,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 12, no. 3 (48), pp. 92–100, 2009, [Online]. Available: https://sid.ir/paper/69395/en

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