COMPARISON BETWEEN ELECTRICAL LESION AND STIMULATION OF NUCLEUS TRACTUS SOLOITARII ON BAROREFLEX SENSITIVITY IN MORPHINE ADDICTED RATS

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POURSHANAZARI A.A.

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Journal: Hormozgan Medical Journal Year:2005 | Volume:9 | Issue:2 Page(s): 101-108

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Title

COMPARISON BETWEEN ELECTRICAL LESION AND STIMULATION OF NUCLEUS TRACTUS SOLOITARII ON BAROREFLEX SENSITIVITY IN MORPHINE ADDICTED RATS

Author(s)

POURSHANAZARI A.A. | | Issue Writer Certificate

Keywords

BAROREFLEXQ4

RATSQ3

MORPHINEQ2

Abstract

Introduction: There is considerable evidence for an interaction between opiate systems and cardiovascular regulatory area in the central nervous system. The endogenous opiate systems are known to depress the BAROREFLEX sensitivity in MORPHINE dependent persons. Nucleus Tractus Soloitarii (NTS) is the principal site of termination of baroreceptor afferent neurons,. We conducted this study to determine the role of electrical stimulation in Nucleus Tractus Soloitarii on BAROREFLEX sensitivity in MORPHINE - addicted RATS.Methods: In this experimental study, male Wistar RATS were addicted during a scheduled 10 day period with MORPHINE sulphate (i.p) and anesthetized by Urethane (150mg/100gr body weight i.v) then cannulasted with PE50 tubs filled with heparin/saline (200u/ml) in femoral artery and vein for recording mean arterial pressure (MAP) and heart rate (HR). The electrodes were induced in NTS, according to paxinous atlas in streotaxic instruments for applying electrical lesion and stimulation. Phenylepherine was used as a vasoconstrictor to induce acute arterial pressure. BAROREFLEX sensitivity was evaluated (HR/MAP) before and after electrical stimulation application in NTS. The control group received saline instead of MORPHINE.Results: The results shows that BAROREFLEX sensitivity has been decreased in MORPHINE addicted RATS compared with control. There are no significant changes in MAP and HR after electrical stimulation application in NTS in both MORPHINE and control groups, but MAP and HR were increased after electrical lesion in both groups. BAROREFLEX sensitivity increased after application of electrical lesion in control (P<0.05) and MORPHINE receiving groups (P<0.05).Conclusion: It is suggested that application of electrical stimulation in NTS can modulate neurotransmission in central nervous system such as GAB Aergic function, therefore this modulation may prevent some abnormality in cardiovascular area in addicted RATS.

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APA: Copy

POURSHANAZARI, A.A.. (2005). COMPARISON BETWEEN ELECTRICAL LESION AND STIMULATION OF NUCLEUS TRACTUS SOLOITARII ON BAROREFLEX SENSITIVITY IN MORPHINE ADDICTED RATS. HORMOZGAN MEDICAL JOURNAL, 9(2), 101-108. SID. https://sid.ir/paper/60160/en

Vancouver: Copy

POURSHANAZARI A.A.. COMPARISON BETWEEN ELECTRICAL LESION AND STIMULATION OF NUCLEUS TRACTUS SOLOITARII ON BAROREFLEX SENSITIVITY IN MORPHINE ADDICTED RATS. HORMOZGAN MEDICAL JOURNAL[Internet]. 2005;9(2):101-108. Available from: https://sid.ir/paper/60160/en

IEEE: Copy

A.A. POURSHANAZARI, “COMPARISON BETWEEN ELECTRICAL LESION AND STIMULATION OF NUCLEUS TRACTUS SOLOITARII ON BAROREFLEX SENSITIVITY IN MORPHINE ADDICTED RATS,” HORMOZGAN MEDICAL JOURNAL, vol. 9, no. 2, pp. 101–108, 2005, [Online]. Available: https://sid.ir/paper/60160/en

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