THE EFFICACY OF MYCOPHENOLATE MOFETIL ON TREATMENT OF NEW LUPUS NEPHRITIS

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SANADGOL H.; ZAKERI Z.; NAJAFI I.; AKBARIAN M.

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Journal: Hormozgan Medical Journal Year:2005 | Volume:9 | Issue:2 Page(s): 93-99

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Title

THE EFFICACY OF MYCOPHENOLATE MOFETIL ON TREATMENT OF NEW LUPUS NEPHRITIS

Author(s)

SANADGOL H. | ZAKERI Z. | NAJAFI I. | AKBARIAN M. | Issue Writer Certificate

Keywords

LUPUS NEPHRITISQ3

PREDNISOLONEQ3

MYCOPHENOLIC ACIDQ3

Abstract

Introduction: Mycophenolate mofetil (MMF) is a new immunosuppressive agenty that selectively inhibits activated lymphoctes and renal mesangial cells.Experience with MMF in solid - organ transplantation has shown the safety of this drug and its superiority over azathioprine (AZA) in the prevention of acute graft rejection. In this study, treatment improvement of LUPUS NEPHRITIS is investigated, using Mycophenolate Mofetil.Methods: We performed a nonrandomized clinical trial in 12 patients with various forms of LUPUS NEPHRITIS (two patients with class V, five patients with class Ill, four patients with class IV) were treated with oral MMF at a dose of 2gr/day and for a mean of 5.38 months range 4-6).All patients were new cases and received concomitant PREDNISOLONE. We started treatment with MMF in all new cases of LUPUS NEPHRITIS. Treatment outcome was monitored through assessment of systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score, renal function, proteinuria and serologic markers such as serum complement and anti dsDNA antibodies. Data were analyzed using Kruscal wallis and Willcoxon statistical tests.Results: While serum createnine remained normal (in 8 patients) or increased less than 33% (in 3 patients). Proteinuria was decreased in 9 cases and Antids DNA was negative in 5 cases. Complete improvement and nelatine improvement of the patients were 36.4% and 45.6%, respectively. Conclusion: Mycophenolate mofetil may represent a valuable alternative to traditional cytotoxic agents for treatment of nephritis. MMF appeared to be effective in controlling serologic disease activity in SLE. Adverse events such as infections may limit its use and remain a concern. MMF should be considered in the treatment of both new cases and resistant LUPUS NEPHRITIS. Controlled clinical trials are required to confirm these findings.

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APA: Copy

SANADGOL, H., ZAKERI, Z., NAJAFI, I., & AKBARIAN, M.. (2005). THE EFFICACY OF MYCOPHENOLATE MOFETIL ON TREATMENT OF NEW LUPUS NEPHRITIS. HORMOZGAN MEDICAL JOURNAL, 9(2), 93-99. SID. https://sid.ir/paper/60166/en

Vancouver: Copy

SANADGOL H., ZAKERI Z., NAJAFI I., AKBARIAN M.. THE EFFICACY OF MYCOPHENOLATE MOFETIL ON TREATMENT OF NEW LUPUS NEPHRITIS. HORMOZGAN MEDICAL JOURNAL[Internet]. 2005;9(2):93-99. Available from: https://sid.ir/paper/60166/en

IEEE: Copy

H. SANADGOL, Z. ZAKERI, I. NAJAFI, and M. AKBARIAN, “THE EFFICACY OF MYCOPHENOLATE MOFETIL ON TREATMENT OF NEW LUPUS NEPHRITIS,” HORMOZGAN MEDICAL JOURNAL, vol. 9, no. 2, pp. 93–99, 2005, [Online]. Available: https://sid.ir/paper/60166/en

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