ASSOCIATION BETWEEN MYASTHENIA GRAVIS AND HLA ANTIGENS IN PATIENTS REFERRED TO SHAFA HOSPITAL, KERMAN

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SHAFA M.A.; VAKILIAN A.R.; AHMADI KOHANALI JAFAR

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Information Journal Paper

Title

ASSOCIATION BETWEEN MYASTHENIA GRAVIS AND HLA ANTIGENS IN PATIENTS REFERRED TO SHAFA HOSPITAL, KERMAN

Author(s)

SHAFA M.A. | VAKILIAN A.R. | AHMADI KOHANALI JAFAR | Issue Writer Certificate

Keywords

MYASTHENIAGRAVISQ4

KERMANQ3

HLA ANTIGENSQ4

GENESQ4

MHC CLASS IIQ4

GENESQ4

MHC CLASS IQ4

Abstract

Introduction: Myasthenia gravis is a disease of neuromuscular junction. Familial cases have been reported. Relation between myasthenia gravis and HLA ANTIGENS has been seen in many studies from different parts of the world. The aim of this study is determination of association between HLA class I haplotypes and myasthenia gravis in KERMAN province. Methods: In this cross sectional study 44 myasthenic patients and 100 healthy control subjects were studied. Microlymphocytotoxicity method was used for HLA typing. Statistical analysis was done using X2 and Fisher exact tests.Results: Prevalence of HLA-A9, A26, A11 in myasthenic patients were significantly lower than healthy control group. Where as, frequency of HLA-B8 in patients group was significantly higher than healthy control group. There was no statistically significant difference between the two groups in other HLA class I haplotypes.Conclusion: Myasthenia gravis is associated with some types of HLA haplotypes. This association can be variable in different parts of the world and in various races. In KERMAN the results of this study indicate that the disease is positively associated with HLA B8 and negatively associated with HLA-A9, All and A26.

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APA: Copy

SHAFA, M.A., VAKILIAN, A.R., & AHMADI KOHANALI, JAFAR. (2004). ASSOCIATION BETWEEN MYASTHENIA GRAVIS AND HLA ANTIGENS IN PATIENTS REFERRED TO SHAFA HOSPITAL, KERMAN. HORMOZGAN MEDICAL JOURNAL, 8(3), 125-128. SID. https://sid.ir/paper/60472/en

Vancouver: Copy

SHAFA M.A., VAKILIAN A.R., AHMADI KOHANALI JAFAR. ASSOCIATION BETWEEN MYASTHENIA GRAVIS AND HLA ANTIGENS IN PATIENTS REFERRED TO SHAFA HOSPITAL, KERMAN. HORMOZGAN MEDICAL JOURNAL[Internet]. 2004;8(3):125-128. Available from: https://sid.ir/paper/60472/en

IEEE: Copy

M.A. SHAFA, A.R. VAKILIAN, and JAFAR AHMADI KOHANALI, “ASSOCIATION BETWEEN MYASTHENIA GRAVIS AND HLA ANTIGENS IN PATIENTS REFERRED TO SHAFA HOSPITAL, KERMAN,” HORMOZGAN MEDICAL JOURNAL, vol. 8, no. 3, pp. 125–128, 2004, [Online]. Available: https://sid.ir/paper/60472/en

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