THE EFFECT OF HYDROALCOHOLIC EXTRACTS OF DOREMA AUCHERI, STACHYS PILIFERA AND TRACHYSPERMUM COPTICUM ON PROLIFERATION OF RAT BRAIN OLIGODENDROCYTES

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MORTAZAVIAN S.M.; HOSAINIAN Z.; GHORBANI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Advances in Medical and Biomedical Research Year:2015 | Volume:22 | Issue:95 Page(s): 59-66

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Title

THE EFFECT OF HYDROALCOHOLIC EXTRACTS OF DOREMA AUCHERI, STACHYS PILIFERA AND TRACHYSPERMUM COPTICUM ON PROLIFERATION OF RAT BRAIN OLIGODENDROCYTES

Author(s)

MORTAZAVIAN S.M. | HOSAINIAN Z. | GHORBANI A. | Issue Writer Certificate

Keywords

DOREMA AUCHERI BOISSQ2

STACHYS PILIFERAQ2

TRACHYSPERMUM COPTICUMQ2

OLN-93 CELL LINEQ2

ANTIPROLIFERATIVE EFFECTQ2

Abstract

Background and Objective: Dorema aucheri, STACHYS PILIFERA and TRACHYSPERMUM COPTICUM are used in Iranian traditional medicine especially in the province of Kohgilouyeh and Boyerahmad. This study aimed to determine the effect of these plants on proliferation of rat brain oligodendrocytes.Materials and Methods: Macerated hydroalcoholic extract of each plant was prepared using 50% ethanol.The OLN-93 oligodendrocytes were incubated for 24 h with different concentrations of these extracts. Then, percentage of viable cells was determined using a method based on the reduction of tetrazolium salt.Results: Extract of Dorema aucheri at 50, 100, 200, and 400 mg/ml decreased viable cells from 100 ± 4% (control cells) to 84± 4, 58 ± 6 (P<0.001), 6 ± 0.5 (P<0.001) and 4 ± 0.5% (P<0.001), respectively.Similarly, STACHYS PILIFERA extract at 50, 100, 200 and 400 mg/ml decreased viable cells from 100 ± 4% to 81± 6, 64 ± 3 (P<0.01), 61 ± 4 (P<0.01) and 55 ± 2% (P<0.001), respectively. Also, TRACHYSPERMUM COPTICUMextract at concentrations higher than 50 mg/ml significantly decreased percentage of viable cells.Conclusion: Extracts of Dorema aucheri, TRACHYSPERMUM COPTICUM and STACHYS PILIFERA reduce proliferation of rat brain oligodendrocytes.

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APA: Copy

MORTAZAVIAN, S.M., HOSAINIAN, Z., & GHORBANI, A.. (2015). THE EFFECT OF HYDROALCOHOLIC EXTRACTS OF DOREMA AUCHERI, STACHYS PILIFERA AND TRACHYSPERMUM COPTICUM ON PROLIFERATION OF RAT BRAIN OLIGODENDROCYTES. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 22(95), 59-66. SID. https://sid.ir/paper/61217/en

Vancouver: Copy

MORTAZAVIAN S.M., HOSAINIAN Z., GHORBANI A.. THE EFFECT OF HYDROALCOHOLIC EXTRACTS OF DOREMA AUCHERI, STACHYS PILIFERA AND TRACHYSPERMUM COPTICUM ON PROLIFERATION OF RAT BRAIN OLIGODENDROCYTES. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2015;22(95):59-66. Available from: https://sid.ir/paper/61217/en

IEEE: Copy

S.M. MORTAZAVIAN, Z. HOSAINIAN, and A. GHORBANI, “THE EFFECT OF HYDROALCOHOLIC EXTRACTS OF DOREMA AUCHERI, STACHYS PILIFERA AND TRACHYSPERMUM COPTICUM ON PROLIFERATION OF RAT BRAIN OLIGODENDROCYTES,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 22, no. 95, pp. 59–66, 2015, [Online]. Available: https://sid.ir/paper/61217/en

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