CORRELATION AMONG CYSTATIN C-BASED FORMULA, SCHWARTZ FORMULA AND CREATININ URINARY CLEARANCE IN GLOMERULAR FILTRATION RATE (GFR) ESTIMATION IN 2-14 YEAR CHILDREN WITH KIDNEY DISEASES

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SAFAEI ASL A.; HEYDARZADEH A.; ENSHAEI M.

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PEDIATRICS Year:2013 | Volume:23 | Issue:1 (SUPPLEMENT) Page(s): 59-59

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Title

CORRELATION AMONG CYSTATIN C-BASED FORMULA, SCHWARTZ FORMULA AND CREATININ URINARY CLEARANCE IN GLOMERULAR FILTRATION RATE (GFR) ESTIMATION IN 2-14 YEAR CHILDREN WITH KIDNEY DISEASES

Author(s)

SAFAEI ASL A. | HEYDARZADEH A. | ENSHAEI M.

Keywords

CREATININE

GLOMERULAR FILTRATION RATE

CYSTATIN C

Abstract

Background: Assessment of glomerular filtration rate (GFR) is an important tool for monitoring renal function. Regarding to particular difficulties in measuring 24 hour urinary creatinine clearance and limitations in available methods, we intended to calculate GFR by cystatin C (Cys C) based formulas and determine correlation rate of them with current methods.Methods: We studied 72 children (38 boys and 34 girls) with several renal disorders such as reflux nephropathy, nephrotic syndrome, renal malformation, obstructive uropathy and hereditary renal disease. The 24 hour urinary creatinine clearance was the gold standard method. GFR also was measured with Schwartz formula (current method in pediatrics) and Cys C-based formulas (Grubb, Simple, Hoek and Larsson). Then correlation rates of these Cys Cbased formulas with the gold standard method and Schwartz formula were determined.Findings: Using Pearson Correlation Coefficient there was positive correlation among all formulas and the standard method (R2 for Schwartz, Hoek, Larsson, Grubb and Simple formula was 0.639, 0.722, 0.705, 0.712, 0.722 respectively), and there was statistically significant correlation (P<0.001). Cys C-based formulas could predict the variance of standard method results with high power.On the other hand, these formulas had correlation with Schwarz formula by R2 0.62-0.65 (intermediate correlation). Also, using Linear Regression and calculating the constant, it revealed that Larsson, Hoek and Grubb formulas can estimate GFR amounts with no statistical difference compared with standard method; but Schwartz and Simple formulas overestimate GFR.Conclusion: This study shows that Cys C-based formlas have strong relationship with 24 hour urinary creatinine clearance. So, it seems that with using these formulas, it is possible to determine GFR in children with kidney injury, easier and with enough correctness. Thereby the physician will be able to treat the renal disease or prevent its progression in early stages and improves the prognosis. Of course, we must emphasize that on the basis of this study, Schwartz and Simple formulas overestimate GFR.

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APA: Copy

SAFAEI ASL, A., HEYDARZADEH, A., & ENSHAEI, M.. (2013). CORRELATION AMONG CYSTATIN C-BASED FORMULA, SCHWARTZ FORMULA AND CREATININ URINARY CLEARANCE IN GLOMERULAR FILTRATION RATE (GFR) ESTIMATION IN 2-14 YEAR CHILDREN WITH KIDNEY DISEASES. IRANIAN JOURNAL OF PEDIATRICS, 23(1 (SUPPLEMENT)), 59-59. SID. https://sid.ir/paper/613059/en

Vancouver: Copy

SAFAEI ASL A., HEYDARZADEH A., ENSHAEI M.. CORRELATION AMONG CYSTATIN C-BASED FORMULA, SCHWARTZ FORMULA AND CREATININ URINARY CLEARANCE IN GLOMERULAR FILTRATION RATE (GFR) ESTIMATION IN 2-14 YEAR CHILDREN WITH KIDNEY DISEASES. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2013;23(1 (SUPPLEMENT)):59-59. Available from: https://sid.ir/paper/613059/en

IEEE: Copy

A. SAFAEI ASL, A. HEYDARZADEH, and M. ENSHAEI, “CORRELATION AMONG CYSTATIN C-BASED FORMULA, SCHWARTZ FORMULA AND CREATININ URINARY CLEARANCE IN GLOMERULAR FILTRATION RATE (GFR) ESTIMATION IN 2-14 YEAR CHILDREN WITH KIDNEY DISEASES,” IRANIAN JOURNAL OF PEDIATRICS, vol. 23, no. 1 (SUPPLEMENT), pp. 59–59, 2013, [Online]. Available: https://sid.ir/paper/613059/en

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