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Information Journal Paper

Title

EVALUATION OF ANTICANCER ACTIVITY OF FRUIT AND LEAVE EXTRACTS FROM VIRUS INFECTED AND HEALTHY CULTIVARS OF VITIS VINIFERA

Pages

  116-123

Abstract

 Objective: Grape VIRUS diseases are a serious problem in Iran. Leaves and fruits of grape have been used for different purposes like cooking in Iran. The present investigation was carried out to study on the cytotoxic-activities of extracts of fruits and leaves of VITIS VINIFERA from both VIRUS-free and VIRUS-infected grape cultivars against breast cancer cell line (MDA-MB-231) and human embryonic kidney normal cell line (HEK 293).Materials and Methods: In this experimental study, the considered grape cultivars were as follows: Rish Baba Sefid, Shahani Ghasre Shirin, Rotabi Zarghan, Asgari Najaf Abad, Fars, Kaj Angor Bojnord, Sarkesh Shiraz and Siahe Zarqan. A real-time multiplex polymerase chain reaction (real-time Multiplex PCR) assay was applied to detect VIRUS infected cultivars. The cytotoxic effect of the methanol extracts of different VITIS VINIFERA varieties on cultured cells was monitored using (3- (4, 5-Dimethylthiazol-2-yl) -2, 5-diphenyltetrazolium bromide (MTT) assay at different concentrations (62.5, 125, 250, 500, 750, 1000 mg mL-1).Results: Among these cultivars, Grapevine fanleaf VIRUS (GFLV) along with related symptoms was detected in Siahe Zarqan and Fars. Methanolic extracts of leaves and fruits of VITIS VINIFERA from both VIRUS free and VIRUS infected cultivars showed a range of limited to moderate cytotoxic activity. However, methanol extract of leaves belonged to VIRUS infected cultivars was found to have strong cytotoxic effect against MDA-MB-231 at different concentrations.Conclusion: Grapevine fanleaf VIRUS (GFLV) can potentially increase the cytotoxicity of grape cultivars.

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    Cite

    APA: Copy

    ESFAHANIAN, ZAHRA, BEHBAHANI, MANDANA, SHANEHSAZ, MEHRNAZ, HESSAMI, MOHAMMAD JAVAD, & NEJATIAN, MOHAMMAD ALI. (2013). EVALUATION OF ANTICANCER ACTIVITY OF FRUIT AND LEAVE EXTRACTS FROM VIRUS INFECTED AND HEALTHY CULTIVARS OF VITIS VINIFERA. CELL JOURNAL (YAKHTEH), 15(2 (58)), 116-123. SID. https://sid.ir/paper/615605/en

    Vancouver: Copy

    ESFAHANIAN ZAHRA, BEHBAHANI MANDANA, SHANEHSAZ MEHRNAZ, HESSAMI MOHAMMAD JAVAD, NEJATIAN MOHAMMAD ALI. EVALUATION OF ANTICANCER ACTIVITY OF FRUIT AND LEAVE EXTRACTS FROM VIRUS INFECTED AND HEALTHY CULTIVARS OF VITIS VINIFERA. CELL JOURNAL (YAKHTEH)[Internet]. 2013;15(2 (58)):116-123. Available from: https://sid.ir/paper/615605/en

    IEEE: Copy

    ZAHRA ESFAHANIAN, MANDANA BEHBAHANI, MEHRNAZ SHANEHSAZ, MOHAMMAD JAVAD HESSAMI, and MOHAMMAD ALI NEJATIAN, “EVALUATION OF ANTICANCER ACTIVITY OF FRUIT AND LEAVE EXTRACTS FROM VIRUS INFECTED AND HEALTHY CULTIVARS OF VITIS VINIFERA,” CELL JOURNAL (YAKHTEH), vol. 15, no. 2 (58), pp. 116–123, 2013, [Online]. Available: https://sid.ir/paper/615605/en

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