EVALUATION OF EFFICACY AND EFFECTIVENESS AZITHROMYCIN AND PREDNISOLONE IN TREATMENT OF CHRONIC PULMONARY COMPLICATION DUE TO MUSTARD GAS

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GHANEEI MOSTAFA; ASLANI J.; PANAHI Y.; AGHAEI MEYBODI S.M.; HOSSEINI SEYED MORTEZA

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Journal: Journal of Military Medicine Year:2008 | Volume:10 | Issue:2 (36) Page(s): 81-87

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Title

EVALUATION OF EFFICACY AND EFFECTIVENESS AZITHROMYCIN AND PREDNISOLONE IN TREATMENT OF CHRONIC PULMONARY COMPLICATION DUE TO MUSTARD GAS

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Keywords

SULFUR MUSTARDQ4

MACROLIDESQ3

AZITHROMYCINQ3

PREDNISOLONE AND BRONCHIOLITE CHRONIC PULMONARY LESIONQ3

Abstract

Introduction: Because of exposing to mustard gas a lot of chemical victims suffer from chronic lung disease (such as chronic bronchitis, bronchiolitis and bronchectasia) and hypersensivity of airways that there are different treatments for controlling symptoms. The aim of this survey is comparing the rate of clinical recovery and lungs function finding in chemical war victims with bronchiolite before and after treatment. The goal of chronic lung disease treatment is achieve to a condition without any symptoms with a good function of lung by using the lowest dose of drugs.Materials and methods: We conducted a prospective self-control clinical trial and enrolled 30 chemical war victims with bronchiolite who came to lung clinics of Baqiyatallah (a.s) hospital, in the six month of 2007. History, physical exams, spirometry, HRCT and completing questionary were done for all patients. Then patient treat by AZITHROMYCIN protocol and prednisolone Results: Twenty eight patients (93.3%) were male and 2 patients (6.7%) were female. The mean age was 44.1±6.1 years old. The mean BMI of patient was 25.7±3.4kg/m2. The mean of FVC percent before and after treatment with full dose were 73.56±11.5 and 73.12±11.2 respectively (p=0.714) and after treating by AZITHROMYCIN & prednisolone was 71.65±12.6 (p=0.491). The mean of FEVI percent before and after treatment with full dose were 62.94±17.8 and 63.51 ±14.6 respectively (p=0.726) and after treating by AZITHROMYCIN & prednisolone was 64±15.2 (p=842). The mean of FEV1/FVC before and after treatment with full dose were 68.4±14.3 and 70±12.9 respectively (p=0.348) and after treating by AZITHROMYCIN & prednisolone was 69±11.3 (p=613).Conclusion: As the patient's didn't show a good response to full dose of corticosteroid. We used AZITHROMYCIN instead of increasing the dose of prednisolone, but the patients didn't show a good response to this new protocol too, due to pathogenesis of SULFUR MUSTARD gas.

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APA: Copy

GHANEEI, MOSTAFA, ASLANI, J., PANAHI, Y., AGHAEI MEYBODI, S.M., & HOSSEINI, SEYED MORTEZA. (2008). EVALUATION OF EFFICACY AND EFFECTIVENESS AZITHROMYCIN AND PREDNISOLONE IN TREATMENT OF CHRONIC PULMONARY COMPLICATION DUE TO MUSTARD GAS. JOURNAL OF MILITARY MEDICINE, 10(2 (36)), 81-87. SID. https://sid.ir/paper/61779/en

Vancouver: Copy

GHANEEI MOSTAFA, ASLANI J., PANAHI Y., AGHAEI MEYBODI S.M., HOSSEINI SEYED MORTEZA. EVALUATION OF EFFICACY AND EFFECTIVENESS AZITHROMYCIN AND PREDNISOLONE IN TREATMENT OF CHRONIC PULMONARY COMPLICATION DUE TO MUSTARD GAS. JOURNAL OF MILITARY MEDICINE[Internet]. 2008;10(2 (36)):81-87. Available from: https://sid.ir/paper/61779/en

IEEE: Copy

MOSTAFA GHANEEI, J. ASLANI, Y. PANAHI, S.M. AGHAEI MEYBODI, and SEYED MORTEZA HOSSEINI, “EVALUATION OF EFFICACY AND EFFECTIVENESS AZITHROMYCIN AND PREDNISOLONE IN TREATMENT OF CHRONIC PULMONARY COMPLICATION DUE TO MUSTARD GAS,” JOURNAL OF MILITARY MEDICINE, vol. 10, no. 2 (36), pp. 81–87, 2008, [Online]. Available: https://sid.ir/paper/61779/en

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