PLURIPOTENT STEM CELLS FOR TOXICOLOGICAL SCREENING AND DISEASE MODELS; INVITED SPEAKERS

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HESCHELER J.

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Journal Paper

Paper Information

Journal: CELL JOURNAL (YAKHTEH) Year:2012 | Volume:14 | Issue:SUPPLEMENT 1 Page(s): 14-15

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Title

PLURIPOTENT STEM CELLS FOR TOXICOLOGICAL SCREENING AND DISEASE MODELS; INVITED SPEAKERS

Author(s)

HESCHELER J.

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Abstract

There is a high need to develop a novel toxicity test platform based on embryonic stem cells (ESCs), in particular human ESC (hESCs), to streamline the drug development RandD process and evaluation of drug toxicity in clinical studies, reduce related costs and thus to not only increase the safety of patients but also to reduce the number of animals due to earlier detection of adverse effects. The FP7 framework consortium ESNATS addresses current shortcomings in toxicity testing: It aims to develop a novel testing system taking advantage of the unique potential of hESCs, including their capacity to self-renew, constituting a potentially unlimited source of cells and their pluripotency, providing a source for cells of different phenotypes required for toxicity testing. Furthermore, hESC-derived somatic cells are physiologically relevant for toxicity endpoints, offering a perspective of tests with improved predictivity. To reach the project goals, a battery of toxicity tests has been developed using hESC lines subjected to standardised culture and differentiation protocols. Genomics approaches are used to determine predictive toxicogenomics signatures. The individual tests will be integrated into an “all-in-one” testing strategy. To ensure practical usage in the pharmaceutical industry, concepts for automated ESC culture will be developed and the test systems will be scaled up. The ESNATS project provides valuable information for risk identification in regulatory toxicology. Alternative testing strategies are highly needed in this field of work to limit the number of animal tests required to comply with the REACH. Moreover, human induced pluripotent stem cells (iPS) will provide additional tools to study the pathophysiology of monogenetic diseases enabling more distinctive and informative assay systems.

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APA: Copy

HESCHELER, J.. (2012). PLURIPOTENT STEM CELLS FOR TOXICOLOGICAL SCREENING AND DISEASE MODELS; INVITED SPEAKERS. CELL JOURNAL (YAKHTEH), 14(SUPPLEMENT 1), 14-15. SID. https://sid.ir/paper/627734/en

Vancouver: Copy

HESCHELER J.. PLURIPOTENT STEM CELLS FOR TOXICOLOGICAL SCREENING AND DISEASE MODELS; INVITED SPEAKERS. CELL JOURNAL (YAKHTEH)[Internet]. 2012;14(SUPPLEMENT 1):14-15. Available from: https://sid.ir/paper/627734/en

IEEE: Copy

J. HESCHELER, “PLURIPOTENT STEM CELLS FOR TOXICOLOGICAL SCREENING AND DISEASE MODELS; INVITED SPEAKERS,” CELL JOURNAL (YAKHTEH), vol. 14, no. SUPPLEMENT 1, pp. 14–15, 2012, [Online]. Available: https://sid.ir/paper/627734/en

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