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Information Journal Paper

Title

THE EFFECTS OF NANO-SILVER AND GARLIC ADMINISTRATION DURING PREGNANCY ON NEURON APOPTOSIS IN RAT OFFSPRING HIPPOCAMPUS

Author(s)

 LALE ATAEI MARYAM | EBRAHIMZADEH BIDESKAN ALI REZA | Issue Writer Certificate 

Pages

  411-418

Abstract

 Materials and Methods: Fifty pregnant wistar rats were randomly divided into five groups: 1- nano- silver (N.S) group; 30 mg/kg of N.S treated via gavage. 2- Control (C) group, administrated with distilled water via gavage. 3- N.S and GARLIC (N.S+G) group; N.S (30 mg/kg) and GARLIC juice (1 ml/100 g) treated via gavage simultaneously. 4- GARLIC group (G); GARLIC juice (1 ml/100 g) administrated via gavage, 5- normal (N) without any intervention. All the interventions were done during pregnancy (21 days). Finally, the brains of rat offspring were removed to use for NANO-SILVER level measurement and TUNEL staining. The mean of TUNEL positive cell numbers per unit area (NA) in different regions of HIPPOCAMPUS were compared in all animal groups.Results: The results revealed a significant increase of HIPPOCAMPUS NANO-SILVER level in N.S and N.S+G groups comparing to N group (P<0.05) and a significant decrease in NANO-SILVER level in N.S+G group comparing to N.S group (P<0.01). The number of TUNEL positive cells in the CA1, CA3, and DG fields of rat offspring HIPPOCAMPUS increased in N.S and N.S+G groups comparing to other ones, and also reduced significantly in N.S+G group comparing to N.S group (¥ P<0.01).Conclusion: Our results showed that co-administration of NANO-SILVER and GARLIC during pregnancy may lead to reduce NANO-SILVER induced apoptotic cells in their offspring HIPPOCAMPUS.

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    • Cite

    APA: Copy

    LALE ATAEI, MARYAM, & EBRAHIMZADEH BIDESKAN, ALI REZA. (2014). THE EFFECTS OF NANO-SILVER AND GARLIC ADMINISTRATION DURING PREGNANCY ON NEURON APOPTOSIS IN RAT OFFSPRING HIPPOCAMPUS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(6), 411-418. SID. https://sid.ir/paper/629223/en

    Vancouver: Copy

    LALE ATAEI MARYAM, EBRAHIMZADEH BIDESKAN ALI REZA. THE EFFECTS OF NANO-SILVER AND GARLIC ADMINISTRATION DURING PREGNANCY ON NEURON APOPTOSIS IN RAT OFFSPRING HIPPOCAMPUS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(6):411-418. Available from: https://sid.ir/paper/629223/en

    IEEE: Copy

    MARYAM LALE ATAEI, and ALI REZA EBRAHIMZADEH BIDESKAN, “THE EFFECTS OF NANO-SILVER AND GARLIC ADMINISTRATION DURING PREGNANCY ON NEURON APOPTOSIS IN RAT OFFSPRING HIPPOCAMPUS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 6, pp. 411–418, 2014, [Online]. Available: https://sid.ir/paper/629223/en

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