مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

APOLIPOPROTEIN E GENE POLYMORPHISM IN IRANIAN CORONARY ATHEROSCLEROSIS PATIENTS CANDIDATE FOR CORONARY ARTERY BYPASS GRAFT

Pages

  841-844

Abstract

 Objective (s): APOLIPOPROTEIN E genotype (APOE) POLYMORPHISM affects lipid levels and coronary artery disease (CAD) risk. The aim of this study was to study the association of the APOLIPOPROTEIN E genotypes with coronary artery disease in the Iranian population.Materials and Methods: The APOLIPOPROTEIN E genotype in DNA samples extracted from 66 CAD+ patients and 61 control subjects by restricting enzyme digestion of amplified exon 4 APOE gene was determined.Results: The ε3 allele was found at similar frequency in control subjects (88.5%) and atherosclerosis patients (83.3%) (P=0.314). Our results showed that the frequency of the e3/e3 and e3/e4 genotypes increased in three-vessel-disease patients and the frequency of e2/e2 genotype increased in one-vessel-disease patients.Conclusion: e3/e3 and e3/e4 genotypes are suggested to be predisposing factors, which, in combination with environmental factors, may trigger the degree of luminal narrowing. The possible mechanisms remain elusive and require further studies.

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    APA: Copy

    HEIDARI, MOHAMMAD MEHDI, FORUZANNIA, SEYED KHALIL, KHATAMI, MEHRI, HADADZADEH, MEHDI, & EMAMI MEYBODI, MAHMOUD. (2013). APOLIPOPROTEIN E GENE POLYMORPHISM IN IRANIAN CORONARY ATHEROSCLEROSIS PATIENTS CANDIDATE FOR CORONARY ARTERY BYPASS GRAFT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(7), 841-844. SID. https://sid.ir/paper/629672/en

    Vancouver: Copy

    HEIDARI MOHAMMAD MEHDI, FORUZANNIA SEYED KHALIL, KHATAMI MEHRI, HADADZADEH MEHDI, EMAMI MEYBODI MAHMOUD. APOLIPOPROTEIN E GENE POLYMORPHISM IN IRANIAN CORONARY ATHEROSCLEROSIS PATIENTS CANDIDATE FOR CORONARY ARTERY BYPASS GRAFT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(7):841-844. Available from: https://sid.ir/paper/629672/en

    IEEE: Copy

    MOHAMMAD MEHDI HEIDARI, SEYED KHALIL FORUZANNIA, MEHRI KHATAMI, MEHDI HADADZADEH, and MAHMOUD EMAMI MEYBODI, “APOLIPOPROTEIN E GENE POLYMORPHISM IN IRANIAN CORONARY ATHEROSCLEROSIS PATIENTS CANDIDATE FOR CORONARY ARTERY BYPASS GRAFT,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 7, pp. 841–844, 2013, [Online]. Available: https://sid.ir/paper/629672/en

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