ANTIOXIDANT EFFECTS OF PROANTHOCYANIDIN FROM GRAPE SEED ON HEPATIC TISSUE INJURY IN DIABETIC RATS

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MANSOURI ESRAFIL; KHORSANDI LAYASADAT; ABEDI HASSAN ALI

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2014 | Volume:17 | Issue:6 Page(s): 460-464

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Information Journal Paper

Title

ANTIOXIDANT EFFECTS OF PROANTHOCYANIDIN FROM GRAPE SEED ON HEPATIC TISSUE INJURY IN DIABETIC RATS

Author(s)

MANSOURI ESRAFIL | KHORSANDI LAYASADAT | ABEDI HASSAN ALI | Issue Writer Certificate

Keywords

ANTIOXIDANT ENZYME

DIABETES

GSP

HEPATIC TISSUE

Abstract

Objective(s): DIABETES plays an important role in the induction of the liver injury. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats.Materials and Methods: Thirty male Sprague-Dawley rats were divided into three groups: control, untreated diabetic and diabetic rats treated with GSP. DIABETES was induced in rats by intraperitoneal injection of streptozotocin (50 mg/kg). GSP were administered via oral gavage (200 mg/kg) for 4 weeks.Results: GSP produced significant hepatoprotective effects by decreasing activities of serum aminotransferases and alkaline phosphatase, and decreasing liver malondialdehyde and bilirubin (P<0.05) levels. It increased liver superoxide dismutase, catalase and glutathione peroxidase activities and albumin level (P<0.05). Administration of GSP significantly ameliorated structural changes induced in liver of diabetic rats.Conclusion: GSP have protective effects against HEPATIC TISSUE injury due to antioxidant properties.

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APA: Copy

MANSOURI, ESRAFIL, KHORSANDI, LAYASADAT, & ABEDI, HASSAN ALI. (2014). ANTIOXIDANT EFFECTS OF PROANTHOCYANIDIN FROM GRAPE SEED ON HEPATIC TISSUE INJURY IN DIABETIC RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(6), 460-464. SID. https://sid.ir/paper/630555/en

Vancouver: Copy

MANSOURI ESRAFIL, KHORSANDI LAYASADAT, ABEDI HASSAN ALI. ANTIOXIDANT EFFECTS OF PROANTHOCYANIDIN FROM GRAPE SEED ON HEPATIC TISSUE INJURY IN DIABETIC RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(6):460-464. Available from: https://sid.ir/paper/630555/en

IEEE: Copy

ESRAFIL MANSOURI, LAYASADAT KHORSANDI, and HASSAN ALI ABEDI, “ANTIOXIDANT EFFECTS OF PROANTHOCYANIDIN FROM GRAPE SEED ON HEPATIC TISSUE INJURY IN DIABETIC RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 6, pp. 460–464, 2014, [Online]. Available: https://sid.ir/paper/630555/en

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