مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

460
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

351
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

2

Information Journal Paper

Title

PERMANENT LESION IN ROSTRAL VENTROMEDIAL MEDULLA POTENTIATES SWIM STRESS-INDUCED ANALGESIA IN FORMALIN TEST

Pages

  209-215

Abstract

 Objective (s): There are many reports about the role of ROSTRAL VENTROMEDIAL MEDULLA (RVM) in modulating stress-induced ANALGESIA (SIA). In the previous study we demonstrated that temporal INACTIVATION of RVM by lidocaine potentiated stress-induced ANALGESIA. In this study, we investigated the effect of permanent LESION of the RVM on SIA by using FORMALIN TEST as a model of acute inflammatory pain.Materials and Methods: Three sets of experiments were conducted: (1) Application of stress protocol (2) Formalin injection after exposing the animals to the SWIM STRESS (3) Either the relevant vehicle or dopamine receptor 1 (D1) agonist R-SKF38393 was injected into the RVM to cause a LESION. For permanent LESION of RVM, R-SKF38393 was injected into the RVM. Forced SWIM STRESS in water was employed in adult male rats. Nociceptive responses were measured by FORMALIN TEST (50ml injection of formalin 2% subcutaneously into hind paw) and pain related behaviors were monitored for 90 min.Results: In the unstressed rats, permanent LESION of the RVM by R-SKF38393 decreased formalin-induced nociceptive behaviors in phase 1, while in stressed rats, injection of R-SKF38393 into the RVM potentiated SWIM STRESS-induced antinociception in phase 1 and interphase, phase 2A of FORMALIN TEST. Furthermore, R-SKF38393 had pronociceptive effects in phase2B whereas injections of R-SKF38393 resulted in significant difference in nociceptive bahaviours in all phases of FORMALIN TEST (P<0.05).Conclusion: The result of the present study demonstrated that permanent INACTIVATION of RVM can potentiate stress-induced ANALGESIA in FORMALIN TEST.

Cites

References

  • No record.

    • Cite

    APA: Copy

    SHAMSIZADEH, ALI, SOLIEMANI, NEDA, MOHAMMADZADEH, MOHAMMAD, & AZHDARI ZARMEHRI, HASSAN. (2014). PERMANENT LESION IN ROSTRAL VENTROMEDIAL MEDULLA POTENTIATES SWIM STRESS-INDUCED ANALGESIA IN FORMALIN TEST. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(3), 209-215. SID. https://sid.ir/paper/631173/en

    Vancouver: Copy

    SHAMSIZADEH ALI, SOLIEMANI NEDA, MOHAMMADZADEH MOHAMMAD, AZHDARI ZARMEHRI HASSAN. PERMANENT LESION IN ROSTRAL VENTROMEDIAL MEDULLA POTENTIATES SWIM STRESS-INDUCED ANALGESIA IN FORMALIN TEST. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(3):209-215. Available from: https://sid.ir/paper/631173/en

    IEEE: Copy

    ALI SHAMSIZADEH, NEDA SOLIEMANI, MOHAMMAD MOHAMMADZADEH, and HASSAN AZHDARI ZARMEHRI, “PERMANENT LESION IN ROSTRAL VENTROMEDIAL MEDULLA POTENTIATES SWIM STRESS-INDUCED ANALGESIA IN FORMALIN TEST,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 3, pp. 209–215, 2014, [Online]. Available: https://sid.ir/paper/631173/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button